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a 60 year old man has been abusing alcohol for years. he appears to have no...

a 60 year old man has been abusing alcohol for years. he appears to have no major medical problems. he has been admitted to outpatien setting for a colonscopy.
a. what elements of his history would alert the nurse to possible problems with pharmacokinetics?

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The patient who admitted for colonscopy is a known history of alcohol consumer which has a negative impact on pharmacokinetics.  It may affect the pharmacokinetics of alcohol by altering the gastric emptying and inhibits gastric alcohol dehydrogenase. The primary site for drug and alcohol metabolism is liver. In liver, the enzymes act on the drug and metabolic break down occurs. When the alcohol circulates in the blood stream it reaches to the liver and these enzymes act on the alcohol and results in oxidation causing high toxic effects as adverse reaction like nuasea, vomiting, facial flushing, tachycardia and hypotension.

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