What is the major product in each of the SN2 reactions below? For each product, label all stereocentres as R or S as
What is the major product in each of the SN2 reactions below? For each product, label...
What is the major product in each of the S 2 reactions below? For each product, label all stereocentres as R or S as appropriate. [8 Marks] CH3CH2SNA acetone Он 1. NaH in THF 2. 1. NaH in THE HS 2. CI сH, NaCN H Br H CH3 acetone CH2CH3
What is the major product in each of the S2 reactions below? For each product, label all stereocentres as R or S as appropriate. [8 Marks] CI CH2CH2SNa acetone 1. Nah in THE no on 2 1. NaH in THE CH3 HBr H+CH3 CH2CH3 NaCN acetone
Problem 10. Draw the structure of the major product formed in each of the following reactions. Consider the resulting stereochemistry of the products formed (6p) KBr ng MeOH NaF DMSO H2(g), Pd (cat.) c) Solvent OH 1) NaH (strong base) THF (solvent) d) 2) CI Nal e) CI Acetone
For each of the following reactions fill in the box to give the missing product(s). If no reaction occurs, write N.R. If the reaction produces a mixture of products, such as stereoisomers or constitutional isomers, give the structure of each product. If a major product arises, label it as so. Be sure to show stereochemistry when needed. 1. NaOH ОН 2. 1-iodopropane THF OH 1. NaH THE 2. 1-bromobutane THF 1. methanol Hg(OAc)2 H2SO4 2. NaBH4 THE H2SO4 YOH 140...
Predict the product(s) of the following reactions, making sure to show all relevant stereochemistry. This includes SN2/E2. State what the major product is. NaOCH2CH3 I À CHỌCH,OH 1. Nah, diethyl ether ONa - er en 10 iv. ochrom NaH JH
4. Give the major organic product(s) for each of the following reactions or sequences of reactions. H Br 1. N.CN 2. NaOH,H,O, heat 3.H30 Ind o do CH,COOH 1. LiAlH, THF, heat 2.H,0 HO CH Br 1. NaCN, acetone 2.H30, heat h ome couco C:03, H30* он
Draw the major product and label as SN2, SN1, E2, or E1 7. Draw the major products of the following reactions, and label the reaction as SN2, SN1, E2 E1. (Darkly shaded bonds are wedged) Br NaOMe NaCN H2SO4 OTs NaSH OTs H20 NaOMe Br KOtBu OH HBr HBr OH
Part II - Reactions (16 marks] Draw the expected major product(s) for each of the following reactions. Question Answer 8. 1. NaH OH ? 2. OTs 9. NBS ? major product 10. Nal Br ? Acetone Br 11. 1. NaNH2 H3C-CECH ? 2. OTS 12. OH Br NaOH ? cyclic compound 13. OH HBT ? 14. ? OH cat. H2SO4 H20 Room temp. 15. Br MeOH
Evening SN2 vs. E2 Homework Predict the major product(s) expected for each of the following reactions. Remember to indica stereochemistry, when appropriate. If no reaction is expected, write NR. a. CH3CN opothe Na t-BuO t-BuOH Rrot b. C. H3C d. H3C Br e. OH EtOH Pro NaN3 OH acetone poic NaOH Stos nlphe h. OTS EtOH pokc
V. What are the major products of the following reactions (if any), and the plausible mechanism (SN1, SN2, E1, E2)? Br NaSCH acetone KO'Bu THF, A NaNH2