Question

Progestin Contraceptives

Give the following information on one of the medication classes above: Drug class, Pharmacokinetics (including absorption, distribution, metabolism, excretion), Pharmacodynamics (including the onset of action, peak effect, duration), and Therapeutic effects.  What are the common side effects and adverse reactions of this drug class?

Answer 1

Progesterone

Class: Hormones from Adrenal cortex

Pharmacokinetics:

Absorption: Serum progestin reaches peak at 2 hours followed by rapid distribution into systemic circulation when administed vaginally.

Distribution : bound to protein from serum 96 to 99%

Metabolism; metabolized by liver

Elimination: by kidneys, bile, feces

Pharmacodynamics:

Action: after 2 hours in peak level. by 24 hours serum level come to baseline.

Duration of action is 24 hours.

half life being 25 to 50 hours. orally given has very short half life.

Therapeutic effect:

1. to prevent endometrial hyperplasia
2. Supplement in ART
3. Embryo implantation
4. Amenorohea
5. abnormal uterine bleeding
6. contraceptive

Side &adverse effects

1. abdominal cramps
2. depression
3. dizziness
4. headache
5. anxiety
6. fatigue
7. irritability etc