Question

Differentiate between the drug effects of the nonselective and selective beta- 1 blockers, and select the major pharmacokinetic differences that exist between the two that can alter the therapeutic response. Duration of action and extent of drug metabolism Onset of action and extent of drug metabolism Duration of action and extent of drug excretion Onset of action and extent of drug absorption

Answer 1

Selective beta blockers -  

A) select the beta receptor located  in the heart tissue. known as Beta 1 receptor

B) decrease activity around heart and can help to reduce heart rate and systolic pressure

C) often used to help condition like chest pain, irregular heart rate, and high heart rate

Non selective beta 1 blockers

A) act on beta 1, beta 2 , beta 3 receptors

B) instead of targeting beta receptor in heart also act on receptors in blood vessels, GI and lungs

C) slow down breathing, prevent hand from trembling, palms from sweating

Major pharmacokinetic difference is duration of action and drug metabolism.

Difference between these two drugs is related to efficacy ( ability to produce desired action)