1. For each of the following substrates, draw the major E2 product if (a) NaOH was...
Draw the major product and
label as SN2, SN1, E2, or E1
7. Draw the major products of the following reactions, and label the reaction as SN2, SN1, E2 E1. (Darkly shaded bonds are wedged) Br NaOMe NaCN H2SO4 OTs NaSH OTs H20 NaOMe Br KOtBu OH HBr HBr OH
1. A) Show each possible product for the reaction below and predict the major product. Be sure. to include all geometric isomers. (1 pt) b Na B) Draw the rotamer that leads to the major product for the reaction above as a Newman projection. (1 pt) 2. Circle the substrates which can undergo elimination through the E2 mechanism. (Hint: substrates may not be drawn in the proper conformation for an E2 reaction). (0.5 pts) to x Kto 3. Circle the...
X Incorrect. Predict the stereochemical outcome for the following E2 reaction. Draw only the major product of the reaction. NaOH CH3 CH3 HC СН3 Edit HC OH CH3
Draw the major organic product(s) of the following reaction.H3C——Br + NaOH →
Evening SN2 vs. E2 Homework Predict the major product(s) expected for each of the following reactions. Remember to indica stereochemistry, when appropriate. If no reaction is expected, write NR. a. CH3CN opothe Na t-BuO t-BuOH Rrot b. C. H3C d. H3C Br e. OH EtOH Pro NaN3 OH acetone poic NaOH Stos nlphe h. OTS EtOH pokc
7.29 Which of the following substrates can undergo an E2 step with H2N as the base? For those that can, draw the curved arrow notation and the products. (a) (b) (c) (d) (e) CI Br Br
Predict the MAJOR product of each of these E2 reaction: Br OCCH) El Porta е оме 3. OMe OME OC(CH3)3 Өоме KOtBu ONa
For each of the following reactions, determine which ELIMINATION mechanism (E1 or E2) will occur. Alkyl Halide Substitution: Methyl 1° 2° 3° Base Strength: Strong Weak Mechanism Type: E1 E2 Draw the mechanism that leads to ALL products for the reaction. Finally, underline the major product of the elimination reaction: H3C OH H2C H2C1 Br CHE
Part II - Reactions (16 marks] Draw the expected major product(s) for each of the following reactions. Question Answer 8. 1. NaH OH ? 2. OTs 9. NBS ? major product 10. Nal Br ? Acetone Br 11. 1. NaNH2 H3C-CECH ? 2. OTS 12. OH Br NaOH ? cyclic compound 13. OH HBT ? 14. ? OH cat. H2SO4 H20 Room temp. 15. Br MeOH
н.W. 10-E2, E1, Sn1 and Sn2 Each substrate undergoes E2 elimination with NaOCHs. Draw the ß-hydrogens, then draw each possible elimination product, and identify the major isomer. The first is shown as an example. Notice he base is a strong base which promotes 2nd order mechanisms Br Br major No need to draw all beta-hydrogens if they are equivalent. minor NaOCH Br Br Br Br