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If large amounts of ethanol metabolism causes a buildup of NADH in cells, What is the...

If large amounts of ethanol metabolism causes a buildup of NADH in cells, What is the response of the Pyruvate Dehydrogenase Complex and how would glycolysis respond to the rising concentrations of NADH?

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Pyruvate dehydrogenase is located in the mitochondrial matrix. During the intermediate state of cellular respiration, this enzyme catalyze the conversion of pyruvate into 2 molecules of acetyl co-enzyme A (Acetyl CoA).

Consumption of ethanol leads to accumulation of NADH (reduced nicotinamide adenine dinucleotide). The higher NADH levels prevent the oxidation of lactate to pyruvate by inhibiting gluconeogenesis. So, the pyruvate dehydrogenase is also inhibited. The conversion of pyruvate to lactate predominates and cause the accumulation of lactate. It may lead to lactic acidosis or hypoglycemia.

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