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The step in metabolism that converts pyruvate to acetyl-CoA involves pyruvate dehydrogenase complex is shown. NADH...
1. The pyruvate dehydrogenase complex converts pyruvate to acetyl-CoA. What are the steps that pyruvate undergoes? Which coenzymes are involved in each step? 2. Mitochondrial extracts from pigeon breast muscle were incubated with Experiment 1: Amytal, an inhibitor of complex I Experiment 2: Malonate, a competitive inhibitor of succinate dehydrogenase Which experiment will yield more ATP when the cycle is primed with intermediates?
Which of the following would not be consistent with the pyruvate dehydrogenase complex? aGeneration of NADH and acetyl CoA b. Inhibition of the complex by pyruvate dehydrogenase phosphatase C. Inhibition by acetyl CoA, NADH, and ATP d. Stimulation by phosphoenolpyruvate
A) Acetyl coA is made from pyruvate in the [ Select ] ["mitochondrial matrix", "cytoplasm", "", ""] by [ Select ] ["pyruvate dehydrogenase", "succinate dehydrogenase"] complex. In this process, the acetyl group is moved between enzymes within the complex by the [ Select ] ["lipoamide", "TPP"] . The [ Select ] ["dihydrolipoyl transacetylase", "pyruvate dehydrogenase component"] is the enzyme in which acetyl coA is actually formed. The [ Select ] ["FADH2", "lipoamide"] in the dihydrolipoyl dehydrogenase donates two electrons to...
The pyruvate dehydrogenase complex catalyzes a multi-step reaction. The key product, acetyl-CoA is released after the third step. What is the purpose of the remaining steps?
4. The pyruvate dehydrogenase complex catalyzes a multi-step reaction. The key product, acetyl-CoA is released after the third step. What is the purpose of the remaining steps?
15. Genetic defect in pyruvate dehydrogenase complex lead a. maple syrup urine disease b. phenyike d. lactic acidemia e. pellagra syrup urine disease b, phenylketonuria c. galactosemia 10. Chemical modification by phosphorylation of pyruvate dehydros a. deactivates the enzyme b. activates the enzyme lation of pyruvate dehydrogenase complex : 17. Pyruvate carboxylase is positively ated through the allosteric mechanism by : a. ATP b. NADH c. Acetyl-SCOA d. TPP e. Biotin 18. Which of the listed coenzymes does not particip...
FAD lipoamide dihydrolipoyl dehydrogenase (E3) pyruvate dehydrogenase (EI) FADH, NAD dihydrolipoyl transacetylase (E2) >NADH + H HOC CH CH3-C- > CH3-C-s pyruvate CH3-C-COA acetyl-CoA COA
1.Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and the rate of glycolysis. Note: pyruvate dehydrogenase is the enzyme that catalyzes the formation of acetyl-CoA from pyruvate. a. Pyruvate dehydrogenase activity will decrease while the rate of glycolysis will increase. b. Both pyruvate dehydrogenase activity and the rate of glycolysis will decrease. c. Pyruvate dehydrogenase activity will increase while the rate of glycolysis will decrease. d. The rate of glycolysis will increase, thereby,...
I1. Mammals lack the enzyme a. Lactate dehydrogenase b. Pyruvate kinase Alcohol Dehydrogenase c. d. Pyruvate decarboxylase None of the above are correct e. 12. The first reaction of the Krebs cycle combines Oxaloacetate and Acetyl CoA to make Citrate b. a. Malate and NADH to make Citrate a-ketoglutarate and citrate to make CO2 d. c- Succinate and Citrate to make Oxaloacetate 13. The electrons held by NADH and FADH, are donated to the which complexes in the ETC respectively?...
Why does acetyl CoA, a product of fatty acid catabolism, influence the pyruvate dehydrogenase complex (PDH), a control point in carbohydrate catabolism? When fatty acid breakdown is high, ADP is low and PDH is inhibited by phosphatase activity. When fatty acid breakdown is inhibited, PDH is inhibited by acetyl CoA due to phosphatase activity. When fatty acid breakdown is high, NADH levels drop, causing an increase in E2 activity. When fatty acid breakdown is high, PDH is inhibited by acetyl...