1.Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and...
1.Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and the rate of glycolysis. Note: pyruvate dehydrogenase is the enzyme that catalyzes the formation of acetyl-CoA from pyruvate.
| a. Pyruvate dehydrogenase activity will decrease while the rate of glycolysis will increase. |
| b. Both pyruvate dehydrogenase activity and the rate of glycolysis will decrease. |
| c. Pyruvate dehydrogenase activity will increase while the rate of glycolysis will decrease. |
| d. The rate of glycolysis will increase, thereby, leading to an increase in pyruvate dehydrogenase activity. |
2. For the following gluconeogenesis reactions, select all of the coupled reactions. NOTE: Pi stands for phosphate.
| a. pyruvate + HCO3- + ATP ⇌ oxaloacetate + ADP + Pi |
| b. phosphoenolpyruvate + H2O ⇌ 2-phosphoglycerate |
| c. fructose-6-phosphate ⇌ glucose-6-phosphate |
| d. 3-phosphoglycerate + ATP ⇌ 1,3-bisphosphoglycerate + ADP |
Homework Answers
Answer 1
Correct option is b) Both pyruvate dehydrogenase activity and the rate of glycolysis will decrease.
Reason: Excess of acetyl CoA prevents its synthesis by pyruvate dehtdrogenase complex.
Also, excess of acetyl CoA inhibits pyruvate kinase thereby increasing phosphoenol pyruvate which then inhibits Phosphofructokinase 1 and hence, rate of glycolysis decreases.
Answer 2
Correct answer is option a) and d)
Coupled reactions are those in which ATP hydrolysis is mandatory as it provides energy for reaction to occur. Reactions in a) and d) require ATP hydrolysis, b) and c) are isomerization reactions and are freely reversible.
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1.Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and...
Part A For the following gluconeogenesis reactions, select all of the coupled reactions. NOTE: Pi stands...
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As we will see in our discussion of lipid metabolism, fatty acid breakdown generates a large...
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3.
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Which of the following glycolytic reactions constitutes a major thermodynamic driving force for glycolysis in vivo? a. Phosphoenolpyruvate + ADP → pyruvate + ATP b. Dihydroxyacetone-PO4 → glyceraldehyde-PO4 c. Glyceraldehyde 3-PO4 + Pi + NAD+ → 1,3-bisphosphoglycerate + NADH + H+ d. 2-Phosphoglycerate → phosphoenolpyruvate + H2O e. Glucose 6-PO4 → fructose 6-PO4
Part A For the following gluconeogenesis reactions, select all of the coupled reactions. NOTE: Pi stands for phosphate. o phosphoenolpyruvate + H20 = 2-phosphoglycerate 0 3-phosphoglycerate + ATP = 1,3-bisphosphoglycerate + ADP o pyruvate + HCO3 + ATP = oxaloacetate + ADP + Pi o fructose-6-phosphate = glucose-6-phosphate
As we will see in our discussion of lipid metabolism, fatty acid breakdown generates a large amount of acetyl-CoA. Part A Predict the effect of a large amount of acetyl-CoA on the activity of pyruvate dehydrogenase and the rate of glycolysis. Note: pyruvate dehydrogenase is the enzyme that catalyzes the formation of acetyl-CoA from pyruvate. O Both pyruvate dehydrogenase activity and the rate of glycolysis will decrease. O The rate of glycolysis will increase, thereby, leading to an increase in...
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1.
2.
3.
4.
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