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Discuss the advantages and disadvantages of prodrugs? Who would benefit from them the most? Why might...

Discuss the advantages and disadvantages of prodrugs? Who would benefit from them the most? Why might a drug company want to develop a prodrug for ADHD?

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Answer #1

Advantages

  • It improves drug delivery
  • To decrease toxicity
  • To target the drug to specific cells/ tissues
  • It is widely used because of its simplicity

Disadvantages

  • Extent of activation may be unreliable especially in liver disease
  • Toxicity due to formation of unexpected metabolite from the total prodrug.

Patients get more benefit from prodrugs by overcoming the barriers presented by other drugs.

The rationale behind development of prodrugs for ADHD is 30 to 40% of patients cannot tolerate side effects of current ADHD Medications.therefor the prodrug lesses the adverse effects and improves patient condition.

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