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The total concentration of receptors in a sample in 10 mM. The concentration of the free...
(4 pts) A sample of cells has a total receptor concentration of 25 mM. Ninety percent...
(4 pts) A sample of cells has a total receptor concentration of 25 mM. Ninety percent of the receptors have bound ligand and the concentration of free ligand is 125 PM. What is the Kd for the receptor-ligand interaction?
A sample of cells has a total receptor concentration of 24 μM, and 35% of the...
A sample of cells has a total receptor concentration of 24 μM, and 35% of the receptors are occupied with ligand. The concentration of free ligand is 10 μM. Calculate Kd. { Kd = [R][L]/[R·L]}.
K, = dissociation constant kon R-receptor L ligand off RIIL K, Total Rec:R,-[R]+[RL] = - Kd...
K, = dissociation constant kon R-receptor L ligand off RIIL K, Total Rec:R,-[R]+[RL] = - Kd ILI QUESTIONS You've identified a drug that has the potential to bind and inhibit 5 different histamine receptors found on human mast cells. The drug if ingested orally typically reaches a concentration of 1 x 108 Molar in the blood stream. Given the K of the drug for each of the 5 receptors listed below, calculate the percentage of receptors occupied with a drug...
Wrine a rate equation depicting the rate of change in the concentration of the protein ligand...
Wrine a rate equation depicting the rate of change in the concentration of the protein ligand eomples formedi acvonding to the reaction below e5 pts ndng Se LP L+P k Protein (P) Protein (P) The reaction above has a 2 onder association rate constant (k.) of 500 mM's and a 1" order dissociation rate constant (ka) of 10 s, What are the equilibrium association (KA) and dissociation (Kn) constants for this basic ligand binding event (I BP) 2.) Use the...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Scatchard analysis may give information about? O A. the ligand binding constant (Kb) of a protein,...
Scatchard analysis may give information about? O A. the ligand binding constant (Kb) of a protein, OB. the number of ligand binding sites on a protein, the type of homotropic cooperativity with ligand binding, OD. Bmax: O E. all of the above, OF. none of the above. In glycolysis, fructose 1,6-bisphosphate is converted to two products with a AG'º of 23.8 kJ/mol. Under what conditions encountered in a normal cell will the free-energy change (AG) be negative, enabling the reaction...
Question 2. The following variables were collected for a random sample of 10 students. Based on...
Question 2. The following variables were collected for a random sample of 10 students. Based on information below, identify and interpret least-squares regression equation. Also, identify and interpret the strength, PRE, direction, and significance of the association between the dependent and independent variable at the alpha level of 0.05. Show five steps if relevant. Obtain all the relevant statistics. Provide a brief overall conclusion. (10 marks) Hours of watching TV a day (X). 6 5 12 10 7 5 6...
41. Which of the following statements about protein-ligand binding is correct? A) The K is equal...
41. Which of the following statements about protein-ligand binding is correct? A) The K is equal to the concentration of ligand when all of the binding sites are occupied. B) The K is independent of such conditions as salt concentration and pH. C) The larger the K. (association constant), the weaker the affinity. D) The larger the K. the faster is the binding. E) The larger the K, the smaller the K. (dissociation constant) 42. The ability of O, to...
2. Calculate free drug concentration for drug A whose unbound percentage is 10 and total drug...
2. Calculate free drug concentration for drug A whose unbound percentage is 10 and total drug concentration is 10 mg/L. 3. Calculate half life of a drug where CL= 101ml/min and V= 17.5 L.
The K+ concentration in an adult blood sample is 4.8*10-3 mol/L. What is the total amount...
The K+ concentration in an adult blood sample is 4.8*10-3 mol/L. What is the total amount of K+ in mEq in this adult? Assume that this adult has a total of 4.7 L of blood.
(4 pts) A sample of cells has a total receptor concentration of 25 mM. Ninety percent of the receptors have bound ligand and the concentration of free ligand is 125 PM. What is the Kd for the receptor-ligand interaction?
K, = dissociation constant kon R-receptor L ligand off RIIL K, Total Rec:R,-[R]+[RL] = - Kd ILI QUESTIONS You've identified a drug that has the potential to bind and inhibit 5 different histamine receptors found on human mast cells. The drug if ingested orally typically reaches a concentration of 1 x 108 Molar in the blood stream. Given the K of the drug for each of the 5 receptors listed below, calculate the percentage of receptors occupied with a drug...
Wrine a rate equation depicting the rate of change in the concentration of the protein ligand eomples formedi acvonding to the reaction below e5 pts ndng Se LP L+P k Protein (P) Protein (P) The reaction above has a 2 onder association rate constant (k.) of 500 mM's and a 1" order dissociation rate constant (ka) of 10 s, What are the equilibrium association (KA) and dissociation (Kn) constants for this basic ligand binding event (I BP) 2.) Use the...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Scatchard analysis may give information about? O A. the ligand binding constant (Kb) of a protein, OB. the number of ligand binding sites on a protein, the type of homotropic cooperativity with ligand binding, OD. Bmax: O E. all of the above, OF. none of the above. In glycolysis, fructose 1,6-bisphosphate is converted to two products with a AG'º of 23.8 kJ/mol. Under what conditions encountered in a normal cell will the free-energy change (AG) be negative, enabling the reaction...
Question 2. The following variables were collected for a random sample of 10 students. Based on information below, identify and interpret least-squares regression equation. Also, identify and interpret the strength, PRE, direction, and significance of the association between the dependent and independent variable at the alpha level of 0.05. Show five steps if relevant. Obtain all the relevant statistics. Provide a brief overall conclusion. (10 marks) Hours of watching TV a day (X). 6 5 12 10 7 5 6...
41. Which of the following statements about protein-ligand binding is correct? A) The K is equal to the concentration of ligand when all of the binding sites are occupied. B) The K is independent of such conditions as salt concentration and pH. C) The larger the K. (association constant), the weaker the affinity. D) The larger the K. the faster is the binding. E) The larger the K, the smaller the K. (dissociation constant) 42. The ability of O, to...
2. Calculate free drug concentration for drug A whose unbound percentage is 10 and total drug concentration is 10 mg/L. 3. Calculate half life of a drug where CL= 101ml/min and V= 17.5 L.
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