Question

:amtro uothop, dier, age 65a. Explain how disruptions in normal microbiota can lead to infections.

Answer 1

Antibiotic disruption of the microbiota of graft recipients, results in increased medial injury of allograft arteries that is reflective of acute vascular rejection not affect intimal thickening reflective of transplant arteriosclerosis. Exacerbated vascular rejection resulting from disruption of the gut microbiota was related to increased infiltration of allograft arteries by neutrophils.

The evidence summarized suggests that disruption of the microbiota through environmental influences may compromise immune function, leading to increased susceptibility to infectious disease. Antibiotic use may paradoxically promote bacterial and viral infections by depleting immune promoting gut bacteria.

Antibiotic resistant microbes, this leads to nosocomial infections by reducing the ability of the immune system to fight infections. Here, antimicrobial use is justified, which speculates the administration of commensal derived products that promote immunity may represent a viable companion therapy to antibiotics. The rise of antibiotic resistance among pathogens and the potential loss of beneficial microbes, support microbiome mediated protection may be an effective approach to achieve resistance to infectious disease in the post antibiotic era.