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65a. Explain how disruptions in normal microbiota can lead to infections
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Disruptions in normal microbiota can lead to infections as the commensal microbiota promotes host resistance against infectious disease by helping in nutrient acquisition, immune development, and neurological function. Further by competing for sites of colonization and nutrient uptake, commensal microbes limit the growth of the pathogens in the host. By priming interleukin-1 (IL-1) β expression commensal microbes lead to immune resistance to pathogen invasion, (Khosravi, 2013)

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