Question

5. Order: Gemzar (gemcitabline HCI) 1.000 mg/m² IVPB add to 200 mL NS infuse in 30 min. The BSA is 0.91 m2. Read the label of this antineoplastic drug in Figure 11.10 and determine the (a) number of mL of diluent you would add to the Gemzar vial. (b) number of mL you would take from the Gemzar vial. (c) pump setting in mL/h. (d) dosage rate in mg/min. Sterle Single-Use Vial VL 7502 Discord Unused portion NOC 0002-7502-01 Exp. Date/Control No WW 2737 AMX GEMZAR gemcitabine for Injection 1g/vial Rx only (OL) 1030002750201L Storage: Prior to and after reconstitution, store at controlled room temperature 20° to 25°C (68° to 77°F) (see USP) To reconstitute: Add 25 mL of 0.9% Sodium Chloride Injection without preservatives) to make a solution containing 38 mg/mL. Shake to dissolve. Administer solution within 24 hours Each vial contains gemcitabine HCl equivalent to 1 g gemcitabine, 1 g mannitol, 62.5 mg sodium acetate, Hydrochloric acid and/or sodium hydroxide may have been used to adjust pH. DO NOT REFRIGERATE Marketed by: Lilly USA, LLC Indianapolis, IN 46205, USA For Intravenous Use Only www.genzar.com SA . Figure 11.10 Drug label for Gemzar. 15 min Find the

please solve using dimensional analysis

Answer 1

Answer = total required dose according to BSA for 0.91m² =1000×0.91

= 910mg

A) 25 ml Normal saline we will add in gemzar vial that will make 38mg/ml

B) 910mg/38=23.94 ml

23.94 ml we will take from gemzar vial

C) pump setting

200 ml ns+ 23.94 ml gamzar solution

=223.94~ is equal to 224ml

Infusion time 30 minutes

( means to make an hour Infusion we should multiply with 2)

=224×2

=448ml/hour Infusion pump setting.

D) Dose rate in mg/ml

Total dose = 910 mg in 30 minutes

910÷30= 30.33mg /minutes

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