Question

You are interested in investigating whether depression is a cause of coronary heart disease(CHD). You decided to set up a population based study. Study participates are randomly selected from a residential list. Persons with a history of CHD at baseline are excluded. Depression at baseline is assessed using a standard Likert instrument. Participants are followed for 10 years with annual follow-up calls in order at assess the occurrence of a coronary heart event. Demographic characterizes are also collected at baseline. At the end of the study 20% of the sample was lost to follow up at varying times.

a. Mention what type of study this is.

b. Mention 2 types of analysis you would use to compare CHD incidence in depressed versus non depressed participants? How do these measures differ in their interpretation?

c. How would you handle those lost to follow up? What will your assumption be?

d. Under what circumstances would losses to follow up result in a biased estimate of the effect of baseline depression on CHD risk?

Answer 1

ANSWERS :

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