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explain the effects of hydrochlorothiazide on the blood pressure

explain the effects of hydrochlorothiazide on the blood pressure

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Hydrochlorothiazide is a thiazide diuretics used to reduce blood pressure.

Contains sulfonamide group that inhibits carbonic anhydrase activity, which may be associated with lower vascular contractility. The drug is concentrated in the kidney and secreted into the tubular lumen, therefore, the therapeutic diuretic effect are often achieved with relatively low plasma concentrations.it

inhibit he sodium-chloride cotransporter in the luminal membrane of the distal convoluted tubule of the ascending loop of Henle, leading to a modest natriuresis and diuresis. The exact mechanism by which they lower blood pressure is not known: while the initial response is from diuresis and volume changes, long-term reduction in blood pressure is through uncertain mechanisms

also increase secretion of potassium and hydrogen ions and promote increased reabsorption of calcium through increased expression of a sodium-calcium exchange channel.

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