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(Crohns disease) What is the overall effect on fluid/electrolyte/acid-base balance of diarrhea on the body?

(Crohns disease) What is the overall effect on fluid/electrolyte/acid-base

balance of diarrhea on the body?

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Ans) IBD-associated mucosal inflammation and the consequent impaired secretion and absorption of electrolytes often result in electrolytic and acid-base imbalance in IBD patients. Reduced sodium and chloride absorption and increased potassium secretion comprise the most common and critical abnormalities.

- Additional amounts of water and electrolytes are lost when there is vomiting, and water losses are also increased by fever. These losses cause dehydration (due to the loss of water and sodium chloride), metabolic acidosis (due to the loss of bicarbonate), and potassium depletion.

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