Question

Exposure assessment in a disastrous case where over 160 cows died (real case!). The compound was Thimet®, which contains 10% phorate and comes in granules. It was estimated that each cow received approximately 10 g of the granules. What was the exposure on a mg/kg body weight basis, assuming the average cow weighs 450 kg?

Answer 1

10 grams = 10,000 milligrams

To know the exposure on mg/kg body weight we have to divide the compound with total body weight

               = 10,000 $\div$ 450

               = 22.22

The affected cow was exposed to 22.22 mg per kg body weight of Thimet granules.