Given
Order:Polymyxin B sulphate
Dose:25,000/kg/day
Frequency:Four times a day
Route:IM
Available:500,000units
Also the 500,000 units in 5ml sterile water
Weight:150 pounds
To convert into kg multiply by 0.454
=0.454×150
=68.1 or 68 kg
If it is 25000/kg
Then for 68.1 kg
Cross multiply and divide
=68.1×25000÷1
=68.1×25000
=1,702,500 units /day
So to calculate one dose divide by 4
=1,702,500÷4
=425,625 units/dose
When 500,000 units =5ml
Then 425,625units=??ml
Cross multiply and divide
=425,625×5÷500,000
=2,128,125÷500,000
=4.25 or 4.3
Ans:4.3ml
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