Aluminum oxide or alumina has been used since 197 as a bulk material in the manufacture of components of the prosthesis and is the inert ceramic most commonly used for surgical implants. It is found in nature as corundum in emery, topaz, amethyst, and emerald. However, it is from the more abundant ores such as bauxite and cryolite and from clays that the material is commercially extracted and purified.
The alumina is used as an articulating surface in hip and knee joints. The ability to be polished to a high surface finish makes it an ideal candidate for this wear application, where alumina operates against materials such as ultrahigh molecular weight polyethylene and alumina itself.
1. Surely the synthetic emerald potentially makes a good articulating surface for artificial implants because due to its ability to be polished to a high surface finish and its excellent wear resistance, this is often used for wear surfaces in joint replacement prosthesis. This application includes femoral heads for hip replacements.
In hip replacements, the alumina femoral head is used in conjunction with a metallic femoral stem and an acetabular cup made from ultra-high-molecular-weight polyethylene or alumina itself for the opposing articulating surfaces.
The success rates depend upon:
a)The frictional and wear behavior of the materials
b)The reliability of the anchorage of the components in their bony environment
Advantages:
-The main advantage is, it not only eliminates the polyethylene from the device system but its extremely low coefficient of friction and potential for far superior wear resistance are very advantageous.
-The usual biologic event is a fibrocytic reaction with very few macrophages and no giant cells.
-Unless there is metallic debris or a very large amount of ceramic debris generated by abnormal contact, or following a long period of component loosening.
-The rate of implant survivorship is satisfactory.
Would a synthetic emerald potentially make a good articulating surface for artificial hip implants? Why or...
Polymer chemistry is a major synthetic tool in material science. In your own words (2 or 3 sentences), describe why industrial laboratories would utilize polymer chemistry to make their products. Remember, industrial laboratories wish to make large quantities of material quickly and cheaply (3 pts) Polymer chemistry is a major synthetic tool in material science. In your own words (2 or 3 sentences), describe why industrial laboratories would utilize polymer chemistry to make their products. Remember, industrial laboratories wish to...
Polymer chemistry is a major synthetic tool in material science. In your own words (2 or 3 sentences), describe why industrial laboratories would utilize polymer chemistry to make their products. Remember, industrial laboratories wish to make large quantities of material quickly and cheaply (3 pts): Polymer chemistry is a major synthetic tool in material science. In your own words (2 or 3 sentences), describe why industrial laboratories would utilize polymer chemistry to make their products. Remember, industrial laboratories wish to...
What amino acid would result from carrying out the following synthetic sequence? Make sure the amino acid has the appropriate charges expected after aqueous workup. Chat amino acid would result from carrying out the following synthetic seguence? Make sure the amino acid has the appropriate charges expected after aqueous workup. 1. NaO EtOH 2. Br(CH2)4NHCOCH3 3. H*, H20, A
1) Show how you would make the following synthetic transformations. More than one step may be required. a) Benzene to 3,5-dibromo-1-ethylbenzene b) benzene to benzylamine (aminomethyl benzene, not aniline) c) benzene to benzonitrile d) methyl orange from sulfanilic acid
If there are internal economies of scale, why would it ever make sense for a firm to produce the same good in more than one production facility?
Osmotic Pressure: You are trying to make artificial blood cells. You have managed to get pure lipids to form spherical bags (cells) of radius 10 μm, filled with hemoglobin. The first time you did this, you transferred the cells into pure water and they promptly burst, spilling the contents. Eventually you found that transferring them into a 1 mM salt solution prevents bursting, leaving the cell spherical and full of hemoglobin and water. Explain the reason why the cells burst...
A. Explain why tosylates make good leaving groups. B. What is the orientation of the stereogenic center after the reaction depicted in the figure? н 1. Cl-Ts, pyridine он (R) 2. SCH3, THF The addition of an acid to an oxirane ring is one of the more non traditional mechanisms in the chapter. Using the posted example, explain, in a stepwise manner, what happens in the mechanism. Be sure to comment on why we see a nucleophile add to the...
l picked ventricular tachycardia. Why would be a GOOD hypothesis that is (specific, testable & reasonable) about the intended drug would have to help patients with ventricular tachycardia. Your group works at a pharmaceutical company that is developing medication to treat these types of heart arrhythmia: e atrial flutter . AV block ventricular fibrillation * ventricular tachycardia Pick ONE of these four types. Do some research and come up with a hypothetical drug to treat this arrhythmia: 1. Provide background...
1 A highly crystalline polymer would probably make a good hydrogel. True False 2. A simple hydrogel loaded with a drug solution and implanted in the body will most likely exhibit drug release kinetics. zero-order sustained instantaneous pulsatile 1 A highly crystalline polymer would probably make a good hydrogel. True False 2. A simple hydrogel loaded with a drug solution and implanted in the body will most likely exhibit drug release kinetics. zero-order sustained instantaneous pulsatile
Based on Albrektsson’s Interpretation: How would you improve Osseointegration? Explain why. 1) increase surface area? 2) increase surface volume? 3) enhance surface bioactivity?