Question

List 4 causes of False negative and False positive result of direct coomb's test List 4 causes of False negative and false positive result of indirect coomb's test

Answer 1

Following are the 4 causes of false negative and false positive result of direct climbs test are :-

False negative direct climbs test , are negative autoimmune hemolytic anemia.even if the result is negative.

Elusion may be performed if immune hemolysis is suspected .

This can be caused by a transfusion of incompatible blood or may be related to conditions HDN

It is also caused by anti complement bovine albumin batched in the trabsfusion.

False positive direct results may be caused by the following over centrifugation or contaminated reagents.

Positive result has antibodies that fight against red blood cells.

It also help to explain symptoms that suggest trouble related blood issues.

A positive direct test result mean your blood and the donors blood are not compatible.

It causes disease like lupus and leukemia.

On the other hand a false negative indirect coombs test is good news , it usually means you don't have antibodies in your serum.

Drug induced antibodies.

Hemolytic transfusion reactions.

Can safely get blood from that donor.

No need of worry to unborn baby.

On the other side false positive indirect coombsctest is a warning that the doctor will have to be careful when choosing donor blood.

If the Rh antibody titer test is positive in a woman who is pregnant has antibodies against Rh positive blood . The mother will be watched closely through out.

If the indirect test results show false positive antibody amounts , the fetus may be at greater risk of harm.

If agglutination occurs the false indirect coombsctest test is positive RBCs are coated with complement.