Which of the following is the reason for administering paclitaxel on a different day as doxorubicin?...
Which of the following is the reason for administering paclitaxel on a different day as doxorubicin?
|
a |
Concurrent administration of taxanes and anthracyclines can increase the risk of heart failure. |
|
b |
Currently there is no data that predicts the cumulative risks of cardiac damage related to their use. |
|
c |
Cumulative doses of radiation and these two agents given together can cause progressive kidney failure. |
|
d |
Cumulative doses of these two agents can result in pulmonary toxicity if given together on the same day. |
Homework Answers
Option 'a' is right,combination of doxorubicin and paclitaxal are used to treat advance breast cancer
But some previous clinical trials suggests that pharmacokonetic interaction between both agent increase the incidence of CONGESTIVE HEART FAILURE
but some recent trials suggests that have limited cumulative doxorubicin dose to 400mg/m square or below with paclitaxal have not observed cardiac toxicity
The conclusion is higher dose of combination of both drug cause congestive heart failure
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Which of the following is the reason for administering
paclitaxel on a different day as doxorubicin?...
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