Question

incidence and global trends predisposing factors of crohn’s disease .

Answer 1

Crohn's disease is a disease which is a chronic disease where the inner lining of the intestine or the digestive tract is affected.

Clinical manifestations:

- chronic pain in the abdomen

- diarrhoea

- loss of weight

- anaemia

- fatigue

Incidence:

In Europe the overall incidence rate of Crohn's disease is about 5.6 of n every 100,000 inhabitants .

In India fewer than 1 million cases are reported every year.

In 2015 in United States around 1.3 % of the population was affected by this disease.

In one of the medical article has stated in march 5 2019 that the diagnosis of Crohn's disease has reached up to 3.1 - 14.6 new cases per 100,000 persons/ year.

The predisposing factors of Crohn's disease are:

More common in developed countries.

- helicobacter pylori causes inflammation of the digestive tract

- family size, sibling ship, and the order of the birth also plays a vital role because the less number of members will have less opportunities to acquire the enteric infection.

- urban environment : the children of urban areas have more chance of getting this disease.

- other childhood factors like: upbringing in the urban will have lack of drinking unpasteurised milk or living in the farms which can lead to the development of Crohn's disease.

Other specific factors are:

- smoking

- oral contraceptives intake

- appendectomy

- diet where the more risk is in the people who consumes sweet, fat, sugar, oil and total fat.