Question

Anorexiants-pharmacodynamics and pharmacotherapeutics (esp. precautions and clinical uses and dosing) Anticonvulsants pharmacodynamics and pharmacotherapeutics (specifically the adverse drug reactions rational selection of the major types) Antidepressants-pharmacodynamics, pharmacokinetics, metabolism and excretion, and pharmacotherapeutics (precautions and contraindications, adverse reactions and clinical uses in the following- TCAS, MAOIS, SSRIS, SNRIIS. How long should it be before patient sees improvement and be familiar with their use in children) Antipsychotics- pharmacodynamics and pharmacotherapeutics Antianxiety and hypnotics-pharmacodynamics and pharmacotherapeutics (pages 267-271). Look at issues of dependence with benzodiazepines. Mood Stabilizers pharmacodynamics and pharmacotherapeutics Muscle relaxants and antispasmotics pharmacodynamics and pharmacotherapeutics Opioids-Classifications, monitoring, withdrawal and patient education (look at Table 15-38)

Answer 1

Anorexiants :

Anorexiants are the drugs that decrease the appetite by acting on the brain. It is short term adjuncts to weight loss for severely obese individuals. These drugs have a stimulant effect on hypothalamic and limbic region which controls satiety.

pharmacodynamics :

Anorexiants are sympathomimetic amines - non amphetamine but chemically and pharmacologically related .

It acts by release and reuptake of norepinephrine and or dopamine that are released from storage sites in nerve terminals in the lateral hypothalamic feeding center.

Pharmacotherapeutic :

precautions :

The drugs should not be used in poorly controlled hypertension and major eating disorder .

These are cautionly used in alcohol dependency .

The drugs should not be used in history of coronary artery diseases , congestive heart failure , arrhythmia , stroke , renal and hepatic diseases.

Clinical uses :

Mainly used to reduce appetite.

These drugs are short term adjunct to caloric restriction for weight loss.

Dose of anorexiants :

The recommended dose of sibutramine is 10 mg per day and after increasing the weight of the person the dose may be increased to 15mg/dl.

The dose of phentermine is 8 mg orally 3 times a day before meals or

15 to 37.5 mg orally once in a week before or 1 to 2 hours after food.