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1. Describe the clinical manifestations of appendicitis with their underlying pathophysiology and associated lab findings. In

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Appendix or the vermiform (vermis = worm) appendix is a narrow worm like tubular structure that projects downward from the cecum. Appendix does not have profound function, but contains lymphoid tissue. Rupture of appendix causes appendicitis, which is an inflammatory condition that requires removal of appendix. Symptoms of appendicitis:

  • Severe pain in the right lower abdominal region
  • Discomfort around the naval region
  • Nausea, vomiting, fever,
  • diarrhoea, or constipation

Rupture of appendix causes appendicitis, which is an inflammatory condition that requires removal of appendix. Pain in the right quadrant of abdominal region occurs during appendicitis. However, most of the elderly individuals does not exhibit the generalized abdominal pain and initial elevation of white blood cell count though they have appendicitis. So, an elderly individual with “generalized abdominal pain” unlikely to have appendicitis.

The symptoms of acute appendicitis occur within 24-48 hours, which is a medical emergency. In chronic appendicitis, the symptoms disappear and reappear over a period of time.

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