Question

Describe the pathophysiology and clinical manifestations of the endocrine system dysfunction seen in children.?

Answer 1

Ans: • Reduction in insulin results in hyperglycemia and deprives cells of fuel

• Cells metabolize fats and proteins causing wastes called Ketone bodies to accumulate in the blood.
• This leads to acidosis.

Clinical manifestation of endocrine system dysfunction:

- There is no specific set of symptoms of endocrine disorders. This is because symptoms will vary depending on the specific kind of endocrine disease a patient has, as well as the severity of his or her condition.

-;For example, hyperthyroidism, a disease marked by the overproduction of thyroxine in the thyroid gland, may cause sudden weight loss, tremors, anxiety, rapid heartbeat, thinning of the skin, and other symptoms. However, diseases of the parathyroid gland can result in a very different set of symptoms, such as lack of energy, depression, osteoporosis, recurrent headaches, kidney stones, and others.

- Though no symptom is universal, weakness and fatigue are commonly reported and it is generally wise for patients to seek medical care upon noticing any significant change in their daily functioning. Because the endocrine system is interconnected and uses hormones to communicate with glands that control and coordinate growth, energy level, reproduction, and other functions, any changes in one gland can cause changes in another.