Question

Chapter 10: Blood and Circulatory System Disorders Case Studies Case Study 1 Mr. X, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia. Discussion Questions 1. Relate the pathophysiology of pernicious anemia to the manifestations listed above. (See Pernicious Anemia.) 2. Discuss how the gastric abnormalities contribute to vitamin B12 and iron deficiency and how vitamin B12 deficiency causes complications associated with pernicious anemia. (See Pernicious Anemia Pathophysiology, Etiology.) 3. Discuss other tests that could be performed to diagnose this type of anemia. (See Pernicious Anemia - Diagnostic Tests.) 4. Discuss the treatment available and the limitations.

Answer 1

is caused the Vitamin Bi2 Pernicious anemia deficiency In this the RBC decsease because of B12 deficiency and folic acid made by the vitamin B 12 Vitamin Bla vich food is poultry, egg, Giay products, meat, Mo x should cat the vitamin Red blood cells ane Vitamin Bla rich food So he can increase his erythrocyte count Vitamin 8la Intrinsic factor is absorbe ol by prokin IF'is producted in CIf) which is a A the stomach .In this anemia ous immune 3 ystem attacks the stomach and destroyes the cells that produce IFbefore the

B 2 is binds -to the If afler consumption Thu gastric abnotmalities dsu/t in vitamin B 12 deftcien ey and ivon deficiency Thus detruction of If" and thus leads to penicious B 2 deficiency cаuse Anemia and RBC decveases Diognostic tets Vitamin B 2 deficiency test Blood count Biopsy IF deficiency test Treatment Injections of vitamin B 12 Replacement treatments limi tations is a Tane condition and deadlly and it does not have complete treatment Causes netVe damage, digustive fraek pro blems, in oun heat, brain other organs may damage body