Ans. Affinity is a measure of the tightness with which a drug bind to the receptor.
Intrinsic activity is a measure of the ability of a drug that is bound to the receptor to generate an activating stimulus and produce a change in cellular activity .
Both agonists and antagonists can bind to a receptor .
Examples 1." : beta adrenoceptor agonists are the most powerful known bronchodilators, and numerous agents of differing pharmacological properties are available for clinical use.
Examples 2. Norepinephrine are full agonists, affinity affects the position of the dose response curve
Norepinephrine would be said to have greater potency than phenylephrine .
QUESTIONS Explain the role of affinity and intrinsic activity in drug-receptor interaction using two different clinical...
QUESTION 4 Using clinical examples, explain why use of hormone replacement therapy for menopause symptoms has significantly declined in the past decade. T Arial 3 (12pt) T o '
Explain what it means when a significant interaction results from a two-way ANOVA T RBC 3 (12pt) T T T Arial
Questions involving numeric data [1.3-1.4] Two common examples of different questions that can come up involving numeric data are writtern below. It is important not to confuse these questions. Answer each for the table below, and explain your answers. 17 8 5 3 -6 4. Do the data represent y as a function of x? Explain why or why not 5. Can the data be modeled by a linear function? Explain why or why not.
Question 4 Multi-Part Questions. Make sure to answer ALL parts (a-c)! You have isolated two versions of the same enzyme, a wild type and mutant. The marteses You have determined the following kinetic characteristics for each of the enzymes. Vmax Wild Type Km 200 umol / min 0.2mm Mutant 2 umol / min 20mm and the reaction is a two-step reaction where k.1 is much larger than k3, which enzyme has the higher affinity for substrate to you You determine...
t. Provide TWO (2) arguments as to why this antibacterial should only be available with a doctor's prescription. (5 marks) Question 4 Recommended time - 20 min Addiction to drugs con coeur due to psychological and/or physical dependence. a Discuss the factors that underlie physical and psychological dependence, explaining the role each plays in addiction. (8 min) b. Compare and contrast the addictive potential of cocaine, LSD and morphine, using your response to (1) and the mechanisms of action of...
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Wave Packets (a) Create a wave by adding two different waves by using Matlab, but different combination than those we used in the class. Paste the output graph (and also the code). Any two waves can be chosen, but explain the difference compared to the original wave packet we obtained in the class. You can modify the code I used in the class, or build something from scratch. (b) Add as much waves as you want (minimum:3), using Matlab. Explain...
Need help answering the two underlined questions using the given diagrams. Thank you Question 1 in red Question 2 in blue In practice, the output of the differentiator in Figure 1 is quite sensitive to the noise perturbation, especially in the high frequency regime (Can you explain why?). For this reason, we incorporate a series resistor at the input as shown in Figure 3 (Can you explain the role of this resistor). N VCC -V cc Figure 1: A simple...
please answer questions 4 and 5 from the scenarios given in the picture. using the PICO questions format and components, develop a clinical question for one of the four scenarios i have provides in the photo and then identify what type of question was it whether quantitative ( 4 types of questions) or qualitative ( 2 types of questions) and indicate which type the questions is quantitative or qualitative and the type. Chapter 2 Fundamentals of Evidence-Based Nursing Practice 29...
Requirement: Answer the following questions: 1. Using the acronym, "A.C.T.L.O.N," identify and explain the sequence the tool recommends you follow to address all medication problems? (6 marks) 2. For each situation below, answer the following questions: a. In your own words, explain the main problem/challenge faced in this situation. (2 marks for each situation) b. What section in the "Medication Problem A.C.T.I.O.N. Plan" resource would you turn to when addressing the situation? (1 mark for each situation) C. What action...