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QUESTIONS Explain the role of affinity and intrinsic activity in drug-receptor interaction using two different clinical examp
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Ans. Affinity is a measure of the tightness with which a drug bind to the receptor.

Intrinsic activity is a measure of the ability of a drug that is bound to the receptor to generate an activating stimulus and produce a change in cellular activity .

Both agonists and antagonists can bind to a receptor .

Examples 1." : beta adrenoceptor agonists are the most powerful known bronchodilators, and numerous agents of differing pharmacological properties are available for clinical use.

Examples 2. Norepinephrine are full agonists, affinity affects the position of the dose response curve  

Norepinephrine would be said to have greater potency than phenylephrine .

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