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Over time, a number of events occurred that helped to form and shape modern oversight of human subjects research. Name four
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1. Nazi atrocities in World War II le d to formulation of the Nuremberg code with establishment of international standard on research with human subjects.

2. The thalidomide disaster resulted in formulation of the "Kefauver Amendments" to the Food, Drug and Cosmetic Act, which made it important for drug manufacturers to prove the drug effectiveness to FDA before marketing them.

3. The Declaration of Helsinki led to formulation of Good Clinical Practices used in present times

4. The Tuskegee Syphilis Study is the worst case in US history about unethical human subjects research.The National Research Act made the protection of human subjects paramount and made the ground for the issuance of the Belmont Report.

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