Alkaptonuria (AKU) is a rare autosomal disorder that causes defects in metabolism of the amino acids phenylalanine and tyrosine. Based on the pedigree below, what is the chance that individual IV-1 will display this trait?
a. 1/16 b. 1/12 c. 1/24 d. 1/18 e. 1/8
Homework Answers
AKU is rare autosomal recessive (as in pedigree two of normal parents have a diseased offspring) disorder. To find out the chances of IV-1 will show the trait or not, lets find out the probability of their parents to be hetrozygous( parents are not homozyous recessive because they do not show the trait, and both parents should have atleast one recessive allele to have a diseased offspring).
IV-1 Father genotype- Brother of IV-1 father have the trait that suggest both of their parents are hetrozygous and probability of IV-1 fathers to be hetrozygous is 2/3(as recessive homozygous condition is not possible as he does not show trait)
IV-1 mother genotype- Her father is certainly hetrozygous as he recieves allele from diseased mother and lets assume her mother normal homozygous (as stated above that this trait is rare). So the probability of IV-1 to be hetrozygous is 1/2.
If both the parents are hetrozygous possibility of offspring showing the trait is 1/4
Possibilty of IV-1 to show the trait is 2/3*1/2*1/4=1/12(option b)
Add Answer to:
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Alkaptonuria is a rare recessive disorder that causes urine to turn black when exposed to air and is caused by a mutation in the homogentisate 1.2-dioxygenase (HGD) gene. Examine the pedigree below and answer the questions. What is the probability that individual A is heterozygous? What is the probability that individual B is heterozygous?
ANSWE THE FOLLOWING QUESTIONS BASED ON THE TEXT ABOVE:
1) The amino acid tyrosine is synthesized from phenylalanine.
Does this make tyrosine an essential amino acid in indivduals with
PKU?
2) In addition to phenylalanine, high levels of what other
compound(s) might show up in the urine of those with PKU?
Why?
THE GENETIC REVOLUTION PKU Phenylketonuria (PKU), the recessively inherited genetic disorder of amino acid metabolism, is regarded as the gold-standard genetic disorder. Its discovery in 1935 laid the...
QUESTION 9 5 pe If the characteristic depicted in the pedigree below is rare and subject to complete penetrance, it is likely to be X-linked recessive? 5 6 7 -OOO No, because individuals ll-2 and 11-4 are not affected No, because individuals 111-4 and III-6 are not affected Yes, because individuals III-4 and III-6 are not affected Yes, because only females are affected in generation 11 1. The gene for cystic fibrosis (normal dominant allele CF and abnormal recessive allele...
how to draw a phylogeny tree
based on the information of amino acids in table 2 ?with
explanation please
by using the amino acid differences between the species in the
table, for example it can be seen that chimpanzees are similar to
humans .....
. S . FEE Table 2 Mitochondrial cytochrome oxidase subunit II (CO II) amino acids (aa) 1-30 of the 227 total aa for the primate species Lemur catta, Paio ursinus, Pan troglodytes, Hylobates lar, Homo sapiens,...
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a.
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b.
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c.
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a.
Autosomal dominant
b.
Autosomal recessive
c.
X-linked dominant
d.
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e.
More than one of the above are possible.
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can
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