Questions 1. Complete the following scheme: 8pts он OH OCH3 1. NaOH 2. Name: Name Name...
H3PO4 OH + OH OH salicylic acid acetic anhydride acetic acid acetylsalicylic acid (aspirin) 1. Why is it better to perform acetylation with acetic anhydride rather than using a Fischer esterification with acetic acid? 2. Draw a complete arrow-pushing mechanism for the reaction. 3. When an old sample of aspirin is left in moist conditions, it will begin to smell like vinegar. Draw a reaction scheme and briefly explain what happened.
29. Draw the product of the following reaction: оо OH + CH3COCCH3 NaOH H20 OH Salicylic acid (o-hydroxybenzoic acid) Acetic anhydride 30. Draw the product of the following reaction: NH2 CH3COCCH3 NaOH H20 HO p-Hydroxyaniline Acetic anhydride
29. Draw the product of the following reaction: O O O C. OH + CH3COCCH3 NaOH H₂O OH Salicylic acid (o-hydroxybenzoic acid) Acetic anhydride
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Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the andient Greeks as a treatment for pain and fever. Salicylic acid (and many related phenols) are very hard on your Ho stomach, but when esterified, as aspirin is, they are much better tolerated. Simple esters are...
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25. Draw the product of the following reaction: CH,BE 1. N&CN, acetone 2. H30, heat 26. Draw the product of the following reaction: CHOy, H,0* OH 27. Draw the product of the following reaction: CN 1. LiAH, THF 2.H309 28. Draw the product of the following reaction: CH3CH2CH2CHCNH, CH.CH SOCI), benzene heat 29. Draw the product of the following reaction: OO OH + CH3COCCH) NaOH H₂O ОН Salicylic acid lo-hydroxybenzoic acid) Acetic anhydride 30. Draw the product...
answer matching questions 37-41
Spring 2019 Matching-Please record answers on the bubble sheet Match the proper structure and name. NO2 OH он CI a) 2-fluoroethylbenzene e) m-chlorobenzoic acid b) 4-isopropylaniline d) 3-methyl-2-nitrobenzoic acid 37. ( poino What is the best name for compound 111? ー38, a poino what is the best naine for compound II? Select the correet intermediates to complete the reaction scheme below CH3 Na H-CEC: 1) 1) NaH MCPBA 2) dilute HCi 2) CHI + enantiomer n)...
1) Which reactant, salicylic acid or acetic anhydride, is in
excess? Show your work.
2) If you were to use 3.17 g of starting material, how much
product would you expect? Again, show your work.
3) Why is phosphoric acid added to the reaction?
4) A small amount of water is added at the end of the reaction
to react with the excess acetic anhydride. Show a balanced equation
for that reaction.
5) Explain the purpose of the FeCl3 test...
Question 1 Fats and oils are: A) Fatty acids B) triglyceride C) steroids D) Simple lipids B Question 2 The isotopically labeled oxygen in aspirin-below- is originally present in which of the following compounds OH bo сн. a) Salicylic acid b) acetic anhydride c) phosphoric acid d) acetic acid А B D Question 3 In synthesis of aspirin after heating for 10-15 minutes, we added water not only to re-crystallize the product, but also A) to force the reaction to...
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don't understand how to do these. Please help. thank you!
25. Draw the product of the following reaction: CH Bt 1. NaN, acetone 2.H30*, heat 26. Draw the product of the following reaction: C:03, H30* OH 27. Draw the product of the following reaction: CN 1. LiA1H, THF 2.H30* 28. Draw the product of the following reaction: CH,CHÚC CH3CH2CH2CHÖNH2 CH2CH3 SOCI, benzene heat 29. Draw the product of the following reaction: O=0 оо он + CH3COCCH3 NaOH H20 OH...
Fill in the table and answer the questions below
Name Pre-lab Questions (10 Marks) 1. Fill the table below: Materials Acetic anhydride H:SO, Salicylic acid Amount 12mL 0.25 mL 3mL Measured Molecular weight (g/mol) Moles 2. Identify the limiting reagent in this reaction? 3. Calculate the theoretical mass yield of Aspirin product? Show your work for full credit. [4] 4. What is the literature melting point of Aspirin (acetyl salicylic acid)?