Question

12. As part of the innate immune defense, which of the following is secreted at epithelial surfaces and directly damages microbial membranes? collectins b. ficollins c. defensins d. C reactive protein antibodies Which of the following complement proteins interact with G-coupled receptors mediating inflammation and migration? c3b C9 c. Cla C5a C2a b. A problem with self/non-self-discrimination in adaptive immunity may to lead to: allergic hypersensitivity autoimmunity immune-deficiency septic shock all of the above Which is true regarding Interleukin-1, Interleukin-6, and Tumor Necrosis Factor? all have systemic effects all are produced by activated macrophages C. all result from NF-kB activation all are considered inflammatory cytokines all of the above are true 16. Which immunological pioneer was among the first to report the existence of phagocytic cells? Jenner Metchnikoff Ehrlich Kitasato Pasteur 17. Among the following, which represents the first step in the process of leukocyte emigration from the blood vessels into inflammatory tissue? a. High affinity LFA-1 binding to ICAMS Leukocyte chemokine receptor engagement with endothelial bound IL-8 E and P selectin upregulation on endothelial cells near inflamed site Leukocyte chemotaxis in inflamed tissue Extravasation of the leukocyte between endothelial cells

Answer 1

1. Option C)

Defensins are the antimicrobial peptides secreted from the epithelium which play an important role in innate immunity. They are cationic peptides that are amphipathic in nature. They produce leaky pores in bacterial cells directly damaging the pathogens. Therefore it is the correct answer.

whereas option a) collectins are a type of pattern recognition receptors found in innate immunity. They are a part of the lectin family. Therefore not the correct answer.

option B) ficolins are also a part of the lectin family. They are involved in the lectin complement pathway. Therefore it is not the correct answer.

option d) C- reactive protein antibodies are involved in inflammation. Therefore not the correct answer.