Synthesis of meta- bromochlorobenzene involves in multiple steps :
1) Nitration of benzene using fuming nitric acid (nitric acid + sulphuric acid)
2) Chlorination of nitrobenzene using FeCl3/Cl2
3) Hydrogenation reaction using Palladium/Carbon catalyst
4) Diazotisation reaction with sodium nitrite
5) Addition of cuprous bromide to the above diazotised product
The reaction is in the below image :
2. (2 pts) Suggest reagents to accomplish the following transformation Br CI
VII. Synthesis: (18 pts) Suggest reagents to accomplish the following transformations. Pay attention to Regiochemistry and Stereochemistry. А. CH3 .CH3 В. NO2 Br
2. (6 pts.) Accomplish the following transformation, showing all synthetic intermediates and reagents. en —
8. Provide the reagents necessary to carry out the following transformation: (10 pts) Ci 9. Provide the reagents necessary to carry out the following conversion: (10 pts) Br Cl
Which set of reagents would best accomplish the following transformation? Teagent i nebent. A) Br, HB B) Br, PBT C) Br, NaOH D) PBT)
Give the reagents needed to accomplish the following transformation. 3. Give the reagents needed to accomplish the following transformation 4.2.
1. Propose suitable reagents to accomplish the following transformations. (3 pts) Br -F (a) Br осн. (b) Br -OH (c)
1. Propose suitable reagents to accomplish the following transformations. (3 pts) Br F (a) Br OCH3 + (b) Br OH (c)
suggest reagents to accomplish the transformation... please do not use the reagent DIBAL-H (: 5-0 H0-0 oba A.
#1 & #2 1. Identify the reagents that you would use to accomplish the following transformation: 5-Y 2. Identify the reagents that you would use to accomplish the following transformation: -
VII. Synthesis: (18 pts) Suggest reagents to accomplish the following transformations. Pay attention to Regiochemistry and Stereochemistry. OXZ (hint: Gabriel?) (hint: protect?)