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Pick one (neutralization, opsonization, or complement fixation) and describe the role of the antibody.

Pick one (neutralization, opsonization, or complement fixation) and describe the role of the antibody.

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Answer #1

Opsonization

pathogens have PAMP (pathogen Associated Molecular Pattern) on the membrane which is recognized by the opsonins proteins like Antibodies. Cell like neutrophils, macrophage and monocytes are not able to recognize and bind directly to the all PAMPs present on the surface of pathogens hence needs the assistance by other cells in order to destroy the pathogen. Antibodies bind to the PAMP by the Fab fragment which has antigen-binding sites by the process known as opsonization and makes them susceptible to phagocytosis. The Fc portion of antibodies remains free. Macrophages, monocytes, and neutrophils have the receptor for the Fc portion of antibodies and bind to the antibodies already bounded with the pathogen this causes the phagocytosis of the antibodies bound pathogen.

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