3. (10 pts) Citrate synthase catalyzes the reaction: Oxaloacetate + acetyl – COA → citrate +...
not sure about reaction 3 and 4 acetyl-CoA COA The reactions of the citric acid cycle are shown in the figure Reactions 1, 3, and 4 are regulation points in the citric acid cycle. 1 citrate oxaloacetate 1 synthase citrate NADH + NAD malate dehydrogenase aconitase 2 malate Which of the molecules inhibits reaction 1? Isocitrate HO 17 fumarase NAD socitrate 3 dehydrogenase S D NADP ADP ОАТР O citrate synthase fumarate FADHI succinate co-ketoglutarate dehydrogenase ci-ketoglutarate NAD dehydrogenase +...
Choose the ONE BEST answer explaining how oxaloacetate and acetyl-CoA levels are balanced to maximize flux through the citrate cycle when energy charge in the cell is lovw Oxaloacetate is required for mitochondrial shuttle systems, and therefore it makes sense to activate pyruvate carboxylase by ATP and inhibit it by malate. None of the answers are correct. The best way to balance the input of carbon into the citrate cycle is to regulate the production of citrate using vitamins like...
Acetyl COA + H2O Coo- o coo- Citrate synthase CH2 -OH -ooc— CH2 CH2 NADH + H+ COO- Oxaloacetate Coo- Citrate Aconitase Malate dehydrogenase NAD+ - Çoo- Çoo- ---OH -O00—-H HO-CH CH2 CH2 Coo- Malate Coo- Isocitrate Isocitrate lyase Malate synthase COO- COO- Coh CH2 Acetyl COA + H2O Ho Glyoxylate coo Succinate Figure 17.23 Biochemistry, Seventh Edition 2012 W. H. Freeman and Company Question 1 (10 pts) Using diagrams show the pathway that is used to convert succinate to...
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled in the diagram, reactions 1, 3, and 4 are regulation points in the citric acid cycle. oxaloacetate citrate synthase citrate NADH +Hi 7 malate dehydrogenase NAD malate aconitase 2 Which molecule inhibits reaction 1? isocitrate 7 fumarase NAD isocitrate dehydrogenase 3 NADH + H+ O citrate O NAD acetyl-CoA + CO2 fumarate C-ketoglutarate FADH succinate O dehydrogenase FAD O-ketoglutarate a dehydrogenase NAD + COA...
Which of the following is an anaplerotic reaction for the citric acid cycle? O conversion of pyruvate to acetyl-CoA O conversion of glutamic acid to e-ketoglutarate O conversion of citrate to oxaloacetate and acetyl-CoA conversion of oxaloacetate to pyruvate O conversion of succinyl-Cos to heme
_--carbon molecule QUESTION 10 During the citric acid cycle, acetyl CoA covalently binds to oxaloacetate to form citrate, a A six B four C. five D. two E three
Succinyl-CoA is a negative regulator of citrate synthase. Explain why this makes sense, and propose a possible mechanism for how this molecule inhibits citrate synthase. What other step of the citric acid cycle is inhibited by succinyl-CoA, and how do you expect that inhibition mechanism to be similar/different?
The first reaction of the citric acid cycle, where acetyle-CoA and combine to form citrate, is catalyzed by OAA; alpha-ketoglutarate dehydrogenase COA; isocitrate dehydrogenase isocitrate; citrate synthase OAA: citrate synthase
Describe “hub” molecules acetyl CoA and pyruvate that serve different pathways. Explain metabolic regulation favoring metabolic pathway choices leading to and from hub molecules. Describe how C.A.C. serves as a “hub “pathway. Use picture as a reference. Pyruvate Glucose Fatty acids sterols pyruvate carboxylase Acetyl-CoA PEP carboxykinase Glutamine Citrate Phosphoenolpyruvate (PEP) Proline Arginine Oxaloacetate PEP carboxylase Citric acid cycle a-Ketoglutarate Malate Glutamate Aspartate Asparagine Serine Glycine Cysteine malic enzyme Purines Succinyl-CoA Phenylalanine Pyrimidines Pyruvate Tyrosine Tryptophan Porphyrins heme Figure 16-16...
the citric acid cycle has 8 enzymes: citrate synthase, aconitase, isocitrase dehydrogenase,.... 1 Jom L C Tegulation TCA cycle (Ch. 16) 1. The citric acid cycle has eight enzymes: citrate synthase, aconitase, isocitrate dehydrogenase, a-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase, and malate dehydrogenase. (a) Write a balanced equation for the reaction catalyzed by each enzyme. (b) Name the cofactor(s) required by each enzyme reaction. (c) For each enzyme determine which of the following describes the type of reaction(s) catalyzed:...