The transition from normal to abnormal at the FMR-1 loci is a multi-step process. The first...

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The transition from normal to abnormal at the FMR-1 loci is a multi-step process. The first...

The transition from normal to abnormal at the FMR-1 loci is a multi-step process. The first event (unequal crossing-over in FEMALES) leads to greater instability. Based on the mechanism of Fragile X, why does the expansion of repeats occur only during meiosis in females? (Draw a SKETCH to demonstrate why you know as well as explaining it).

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Answer 1

Answer #1

The fragile X syndrome due to abnormal FMR1 loci pathway is described in this diagram:

7-52 CGG repeats Bind: mRNA Regulates translation protein synthesis CpG lsland This is a case when there is normal FMR1 rene 200 CGG r CpG lsland RGGI Hypermethylati on/Reassociatio FMR1 silencing n of acetylated histones or RNA interference Fragile X phenotype Abnormal dentric development No translational inhibition

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