DQuestion 1 1 pts See Figure 11-1. To make Compound 1 using the malonic ester synthesis,...
What are the steps to make this compound via malonic ester synthesis?
10. Select the compound that can not be made using the malonic ester synthesis: O o O OH MeO OMe OH Ph ОН A. B. Ph C. D. 11. In general both the malonic ester and acetoacetate synthesis require the addition of dilute acid in order to generate the final product. Why? A. the alkoxy cation needs to be eliminated C. the ionized cation partitions to the aqueous layer B. the stabilized enolate adds a proton in the separatory funnel...
Outline all steps in a synthesis of the following compound using the malonic ester synthesis method: CH_3 (CH_2)_2 CH_2 - CO_2 H.
10. Select the compound that can not be made using the malonic ester synthesis: O O OH MeO Оме OH Ph OH A. B. Ph C. D. 11. In general both the malonic ester and acetoacetate synthesis require the addition of dilute acid in order to generate the final product. Why? A. the alkoxy cation needs to be eliminated C. the ionized cation partitions to the aqueous layer B. the stabilized enolate adds a proton in the separatory funnel D....
Question The malonic ester synthesis has been used countless times to make bioactive molecules. One example is the synthesis of barbiturates. Your answer O a. = OEt Ob. Barbiturates are sedative-hypnotic drugs, which can have many effects ranging from sedation to anesthesia, and even death by acting as central nervous system depressants. Barbiturates are commonly prescribed medications, but are also for several non-therapeutic purposes (often illegally). = Et One particularly famous barbiturate is sodium thiopental, which has been used in...
6. Using either malonic ester synthesis or acetoacetic ester synthesis, outline a reaction scheme in each case to show how you will synthesize compounds A and B below. [Show all steps with structure of all intermediates and necessary reagents). A. 3-butyl-2-tetradecanone B. 2-propylpentadecanoic acid
11) Show how to synthesize 2-Methylhexanoic acid using the Malonic Ester Synthesis. Start with Diethyl propanedioate (C7H1204)
show how you would make this compound... 2. Show how you would make this compound by a malonic ester synthesis or an acetoacetic acid synthesis. 4-methylhexanoic acid
3) Which of the following acids can be prepared by a malonic ester synthesis? Show th steps and the reagents you would use. соон b) a) COOH c) COOH d) 4) The following compounds can be made using the aldol condensation. Write the steps and reagents you would use. -CHO b) a) CHO c) он d) он о
11. In general both the malonic ester and acetoacetate synthesis require the addition of dilute acid in order to generate the final product. Why? C. the ionized cation partitions to the aqueous layer A. the alkoxy cation needs to be eliminated in the separatory funnel B. the stabilized enolate adds a proton D. this generates heat leading to decarboxylation 14. Which reagent(s) is(are) needed to complete the desired synthesis?: O ? A. NaOM, H Meo Н. I dil. HCI B....