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Which epigenetic mark is most often associated with genes that are inactive for the lifetime of the cell?

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Answer #1

Epigenetic is the study of changes in gene expression which does not changes the sequence of the gene. These changes are heritable. So there is two type of most often gene-associated markers.

1. Chemical ( eg DNA Methylation)

2. Protein ( eg Histone modification)

Due to the plasticity of DNA methylation, it is reversible most of the time but In females, random X-chromosome inactivation is initiated during gastrulation in the epiblast through the X-inactive specific transcript (Xist) gene, which encodes a long non-coding RNA that silences the X-chromosome. In human females, this is also known as a Bar Body.

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