Which of the following is a false statements about tumor suppressor genes? Gene amplification (duplication) of...
Which of the following is a false statements about tumor suppressor genes?
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Gene amplification (duplication) of a tumor suppressor gene is less likely to result in cancer than gene amplification of a proto-onocogene. |
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Individuals with a single normal copy of a tumor suppressor gene are more prone to cancer than those with two normal copies. |
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Inactivation of tumor suppressor genes can lead to enhanced cell survival and cell proliferation. |
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Epigenetic changes that silence tumor suppressor genes would not lead to cancer. |
Homework Answers
Individuals with a single normal copy of a tumor suppressor gene are more prone to cancer than those with two normal copies.Is false
Generally one copy of a tumor-suppressor gene suffices to control cell proliferation, both alleles of a tumor-suppressor gene must be lost or inactivated in order to promote tumor development.
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Which of the following is a false
statements about tumor suppressor genes?
Gene amplification (duplication) of...
Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cance...
Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene? Given that is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without...
Contrast what tumor suppressor genes and proto-oncogenes do in their normal and cancer-promoting states. Normal ...
Contrast what tumor suppressor genes and proto-oncogenes do in their normal and cancer-promoting states. Normal Cancer-promoting Tumor suppressor gene (Proto-)oncogene
A tumor suppressor gene is best described by which of the following? a. when it is...
A tumor suppressor gene is best described by which of the following? a. when it is expressed, the gene suppresses viral genes from being expressed b. a gain-of-function mutation lead to uncontrolled proliferation c. when it is express, the gene induces tumor formation d. a loss-of-function mutation leads to uncontrolled proliferation e. when it is expressed, the gene specifically blocks the G 1/S checkpoint.
13. Which of these statements is TRUE? a. Cancer cells usually have more than one mutation....
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There are two main types of cells in the human brain, neurons (nerve cells) and glial cells (supporting cells). Once neurons fully mature, these nerve cells no longer divide. Glial cells, however, continue to divide over a person’s entire lifetime. GDNF (glial cell line-derived neurotrophic factor) is a small protein that stimulates growth in glial cells. What kind of signal molecule is this protein? How does GDNF likely promote cell division? After the glial cell receives GDNF, what will happen...
Retinoblastoma (resulting in eye tumor) results from inactivation of Rb gene, a tumor suppressor. A).List the molecular events that lead to the development of hereditary retinoblastoma? _____________...
Retinoblastoma (resulting in eye tumor) results from inactivation of Rb gene, a tumor suppressor. A).List the molecular events that lead to the development of hereditary retinoblastoma? ________________________________________________________________________________________________________________________________________________________________________________________________ B). How the development of sporadic retinoblastoma will be different from the hereditary one? Mention the molecular steps that will be unique for the sporadic retinoblastoma? _________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ C). Is the loss of Rb function dominant or recessive and why? ________________________________________________________________________________________________________________________________________________________________________________________________ D). Knowing the Rb binds to E2F, which is transcription factor activating expression...
please help me with this genetics question! thank you! TS =Tumor Suppressor genes O = Oncogenes...
please help me with this genetics question! thank you!
TS =Tumor Suppressor genes
O = Oncogenes
5A. (12pts) Cancer is a genetic disease. Some of the causative mutations are Tumor Suppressor genes, and others convert proto-oncogenes into Oncogenes. In the list of properties below, mark an X in the column for TS, O, or both. TS O both Causes of inherited elevated cancer risk. Leads to uncontrolled cell growth. Typically, spontaneous, gain-of-function mutations. Can cause increased DNA damage. Dominant in...
Consider a spontaneous mutation in the gene HER2, a tumor suppressor involved in cell cycle control...
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please help me with this genetics question! thank you!
TS =Tumor Suppressor genes
O = Oncogenes
5A. (12pts) Cancer is a genetic disease. Some of the causative mutations are Tumor Suppressor genes, and others convert proto-oncogenes into Oncogenes. In the list of properties below, mark an X in the column for TS, O, or both. TS O both Causes of inherited elevated cancer risk. Leads to uncontrolled cell growth. Typically, spontaneous, gain-of-function mutations. Can cause increased DNA damage. Dominant in...
Consider a spontaneous mutation in the gene HER2, a tumor suppressor involved in cell cycle control Mutations happen at a rate of about 1 error per 109 bases per generation. A spontaneous deleterious mutation must occur in HER2 specifically, and not in another gene. The likelihood that a spontaneous mutation is deleterious and could lead to cancer depends on the number of mutable bases in HER2, the fraction of bases that will affect the function of HER2, and that both...
PATH370 2018 - risk factors/predisposing factors for carcinogenesis: tobacco, nutrition, genetics (proto-oncogenes, oncogenes, tumor suppressor genes), viruses - role of p53 and Rb carcinogenesis: what is initiation, promotion, progression? - carcinogen vs mutagen vs teratogen - metastasis: define/describe, pattern of spread, tumor markers, angiogenesis, grading/staging, most common organs where metastasis occurs, first place of metastasis for many cancers - TNM system: what does each letter represent, are low or high number more severe? - generalized effects of cancer on the...
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