Williamson Ether Synthesis of Guaifenesin Starting Materials - 2-methoxyphenol (guaiacol): 550 uL - 3-chloro-1,2-propanediol: 500 uL...
Williamson Ether Synthesis of Guaifenesin
Starting Materials
- 2-methoxyphenol (guaiacol): 550 uL
- 3-chloro-1,2-propanediol: 500 uL
- Sodium hydroxide: 1 mL of 6M
Product
- Guaifenesin
What is the yield expected in (g) and (mmoles)?
Homework Answers
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Williamson Ether Synthesis of Guaifenesin
Starting Materials
- 2-methoxyphenol (guaiacol): 550 uL
- 3-chloro-1,2-propanediol: 500 uL...
can you help me calculate the theoretical yield calculations for 2 methoxyphenol and 3-chloro-1,2-propanediol THE laboratory...
can you help me calculate the theoretical yield calculations for
2 methoxyphenol and 3-chloro-1,2-propanediol
THE laboratory The essential reactants guaifenesin synthesis are provided in Table 1. Table 1. Compound 2-methoxyphenol bp (°C) Reactants used amount used mmol 550 L calculate MW 124.14 d (g/mL) 1.13 NaOH (25% soln.) 40 do 1 mL obno ethanol 46.07 18 water 142.04 1.32 Sodium sulfate calculate 110.54 500 L (+)-3-chloro-1,2- propanediol 164
6. Write the theoretical yield calculations for this reaction In the laboratory The essential reactants guaifenesin...
6. Write the theoretical yield calculations for this
reaction
In the laboratory The essential reactants guaifenesin synthesis are provided in Table 1. Table 1. Compound 2-methoxyphenol bp (°C) Reactants used amount used mmol 550 L calculate MW 124.14 d (g/mL) 1.13 NaOH (25% soln.) 40 1 mL ethanol 46.07 18 water Sodium sulfate (+)-3-chloro-1,2- propanediol 142.04 110.54 500 uL calculate 1.32
What happens if the base (NaOH) is added after the alkyl halide (solution made with 3-chloro-1,2-propanediol...
What happens if the base (NaOH) is added after the alkyl halide (solution made with 3-chloro-1,2-propanediol and 95% ethanol) during the Williamson ether synthesis? Support your answer with a chemical equation identyfing the side product.
Write detailed, reaction mechanism of guaifensin synthesis. Must include arrows, electron flow and lone pairs. 100...
Write detailed, reaction mechanism of guaifensin synthesis. Must
include arrows, electron flow and lone pairs.
100 Pre-lab preparation BREE In your lab notebook, prepare the following (see lab notebook guide for details): Jl. Write all procedures required for this experiment. Prepare it so that it can be used as a sole source of your experimental procedures 2. In your notebook, draw structures of both enantiomers of 3-chloro-1.2-propanediol 3. In few sentences summarize main factors that have influence on Sw2 type...
Need help, numbers 3-6 please show work. and fill out table of chemicals for all chemical...
Need help, numbers 3-6 please show work. and fill out table of
chemicals for all chemical used.
calculate mmol in the table as well show work please
and each of these must be listed in its own row. There are 10 column headings: IUPAC name OR common name, structure, CAS number (Chemical Abstract Service number) molecular mass, melting point (if applicable), boiling point (if applicable), solubility (in water, if applicable), density, amounts to be used in the experiment, and the...
This is a williamson ether synthesis SN2 reaction. what are the complete mechanisms of this reaction,...
This is a williamson ether synthesis SN2 reaction. what are
the complete mechanisms of this reaction, with the intermediates
included?
MLNVILI SYNTHESIS OF 2-BUTOXYNAPHTHALENE OH 1. NaOH, ETOH 2. n-BuBr DISCUSSION: Nucleophilic substitution reaction is a frequently used method to convert one functional group into another. A nucleophile is mixed with an electrophile and the nucleophile replaces the leaving group to produce a new compound. In this experiment, a weak nucleophile (2-naphthol) is converted into a strong nucleophile. Then this...
What would have been the best starting materials for the synthesis of R-2-ethoyxbutane? 3. A student...
What would have been the best starting materials for the
synthesis of R-2-ethoyxbutane?
3. A student wanted to make R-2-ethoxybutane, using the Williamson ether synthesis. He remembered that the Williamson synthesis involves an SN2 displacement, which takes place with inversion of configuration. He ordered a bottle of S-2-butanol for his chiral starting material. He also remembered that SN2 goes best on primary halides, so he made ethyl bromide and S-2-sodiumbutoxide. After warming these reagents together, he obtained an excellent yield...
Please help with calculating the yield on this first page...the other two are data for your...
Please help with calculating the yield on this first page...the
other two are data for your calculations. I believe the limiting
agent is 2-methoxyphenol, but I don't know how to calculate the
percent yield, or how to set that up...thank you
We were unable to transcribe this imageCHEM 246 Fundamentals of Organic Chemistry Laboratory Experimental Procedure Day 1 1. Bring a 50 mL round bottom flask, a yellow cap, and a cork ring to the reagent hood, measure 1 mL...
in the solvolysis of 2-chloro-2-methylpropane, some di-t-butyo ether is formed. Explain rhis phenomenon in your own...
in
the solvolysis of 2-chloro-2-methylpropane, some di-t-butyo ether
is formed. Explain rhis phenomenon in your own words and show the
reaction sequence that represents this, starting with your starting
materials.
Complete and turn in the problems below. 1. Using an equation like equation 3, derive the expression for k given in equation 4. 2. What solvent mixture are you using in parts A-C? In part D? What effect will the different solvent system used in part D have on the...
Just Answer Question 5 Synthesis of 2-chloro-2-methylbutane (literature version) Concentrated aqueous hydrochloric acid (HCI, 3.3 equivalents)...
Just Answer Question 5
Synthesis of 2-chloro-2-methylbutane (literature version) Concentrated aqueous hydrochloric acid (HCI, 3.3 equivalents) was slowly added to 2-methyl-2-butanol (1.0 equivalents) in a 100 mL round bottom flask with stirring. The reaction was stirred for 15 minutes at room temperature. Upon completion, the reaction mixture was transferred to a 60 mL separatory funnel and the aqueous layer was removed. The organic layer (i.e. the product) was successively washed with: (1) saturated aqueous NaCl (brine), (2) saturated aqueous NaHCO,...
can you help me calculate the theoretical yield calculations for
2 methoxyphenol and 3-chloro-1,2-propanediol
THE laboratory The essential reactants guaifenesin synthesis are provided in Table 1. Table 1. Compound 2-methoxyphenol bp (°C) Reactants used amount used mmol 550 L calculate MW 124.14 d (g/mL) 1.13 NaOH (25% soln.) 40 do 1 mL obno ethanol 46.07 18 water 142.04 1.32 Sodium sulfate calculate 110.54 500 L (+)-3-chloro-1,2- propanediol 164
6. Write the theoretical yield calculations for this
reaction
In the laboratory The essential reactants guaifenesin synthesis are provided in Table 1. Table 1. Compound 2-methoxyphenol bp (°C) Reactants used amount used mmol 550 L calculate MW 124.14 d (g/mL) 1.13 NaOH (25% soln.) 40 1 mL ethanol 46.07 18 water Sodium sulfate (+)-3-chloro-1,2- propanediol 142.04 110.54 500 uL calculate 1.32
Write detailed, reaction mechanism of guaifensin synthesis. Must
include arrows, electron flow and lone pairs.
100 Pre-lab preparation BREE In your lab notebook, prepare the following (see lab notebook guide for details): Jl. Write all procedures required for this experiment. Prepare it so that it can be used as a sole source of your experimental procedures 2. In your notebook, draw structures of both enantiomers of 3-chloro-1.2-propanediol 3. In few sentences summarize main factors that have influence on Sw2 type...
Need help, numbers 3-6 please show work. and fill out table of
chemicals for all chemical used.
calculate mmol in the table as well show work please
and each of these must be listed in its own row. There are 10 column headings: IUPAC name OR common name, structure, CAS number (Chemical Abstract Service number) molecular mass, melting point (if applicable), boiling point (if applicable), solubility (in water, if applicable), density, amounts to be used in the experiment, and the...
This is a williamson ether synthesis SN2 reaction. what are
the complete mechanisms of this reaction, with the intermediates
included?
MLNVILI SYNTHESIS OF 2-BUTOXYNAPHTHALENE OH 1. NaOH, ETOH 2. n-BuBr DISCUSSION: Nucleophilic substitution reaction is a frequently used method to convert one functional group into another. A nucleophile is mixed with an electrophile and the nucleophile replaces the leaving group to produce a new compound. In this experiment, a weak nucleophile (2-naphthol) is converted into a strong nucleophile. Then this...
What would have been the best starting materials for the
synthesis of R-2-ethoyxbutane?
3. A student wanted to make R-2-ethoxybutane, using the Williamson ether synthesis. He remembered that the Williamson synthesis involves an SN2 displacement, which takes place with inversion of configuration. He ordered a bottle of S-2-butanol for his chiral starting material. He also remembered that SN2 goes best on primary halides, so he made ethyl bromide and S-2-sodiumbutoxide. After warming these reagents together, he obtained an excellent yield...
Please help with calculating the yield on this first page...the
other two are data for your calculations. I believe the limiting
agent is 2-methoxyphenol, but I don't know how to calculate the
percent yield, or how to set that up...thank you
We were unable to transcribe this imageCHEM 246 Fundamentals of Organic Chemistry Laboratory Experimental Procedure Day 1 1. Bring a 50 mL round bottom flask, a yellow cap, and a cork ring to the reagent hood, measure 1 mL...
in
the solvolysis of 2-chloro-2-methylpropane, some di-t-butyo ether
is formed. Explain rhis phenomenon in your own words and show the
reaction sequence that represents this, starting with your starting
materials.
Complete and turn in the problems below. 1. Using an equation like equation 3, derive the expression for k given in equation 4. 2. What solvent mixture are you using in parts A-C? In part D? What effect will the different solvent system used in part D have on the...
Just Answer Question 5
Synthesis of 2-chloro-2-methylbutane (literature version) Concentrated aqueous hydrochloric acid (HCI, 3.3 equivalents) was slowly added to 2-methyl-2-butanol (1.0 equivalents) in a 100 mL round bottom flask with stirring. The reaction was stirred for 15 minutes at room temperature. Upon completion, the reaction mixture was transferred to a 60 mL separatory funnel and the aqueous layer was removed. The organic layer (i.e. the product) was successively washed with: (1) saturated aqueous NaCl (brine), (2) saturated aqueous NaHCO,...
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