Guaifenesin Synthesis
Procedure:
2-methoxy phenol (550 uL), NaOH (25% Soln) (1 mL) and (±)-3-Chloro-1,2-propanediol (500 uL) charge into single neck round bottomed flask with magnetic stirring bar and then placed the reaction mass flask on heating magnetic stirrer with oil bath. Heat the reaction mass up to 50°C, maintained the reaction under stirring for 1 hour at 50°C condition. Cool the reaction mixture and then extracted the product with ethyl acetate two times each 2ml. The organic layer dried with Sodium Sulfate and evaporated the ethyl acetate till dryness. The crude product recrystallized by ethanol and water system then isolate the product by filtration. The solid product dried.
Enantiomer of 3-Chloro-1,2-propanediol
Mechanism for Guaifenesin Synthesis:
Yield:
Theoretical yield calculation
621.5 × 198.21 = 992.33 mg so the theoretical yield is 992.33 mg
124.14
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Write detailed, reaction mechanism of guaifensin synthesis. Must include arrows, electron flow and lone pairs. 100...
6. Write the theoretical yield calculations for this reaction In the laboratory The essential reactants guaifenesin synthesis are provided in Table 1. Table 1. Compound 2-methoxyphenol bp (°C) Reactants used amount used mmol 550 L calculate MW 124.14 d (g/mL) 1.13 NaOH (25% soln.) 40 1 mL ethanol 46.07 18 water Sodium sulfate (+)-3-chloro-1,2- propanediol 142.04 110.54 500 uL calculate 1.32
can you help me calculate the theoretical yield calculations for 2 methoxyphenol and 3-chloro-1,2-propanediol THE laboratory The essential reactants guaifenesin synthesis are provided in Table 1. Table 1. Compound 2-methoxyphenol bp (°C) Reactants used amount used mmol 550 L calculate MW 124.14 d (g/mL) 1.13 NaOH (25% soln.) 40 do 1 mL obno ethanol 46.07 18 water 142.04 1.32 Sodium sulfate calculate 110.54 500 L (+)-3-chloro-1,2- propanediol 164
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