Question

A 75-year-old man was found unconscious in his bathroom after faltling and hitting his head. He survived for several hours but died later in the hospltal An autopsy was performed to determine the exact cause of death Evidence indicated that the man had suffered two strokes, both due to blocked blood vessets. One had occurred a few weeks earler, the other had occured very recently and may have led to the tall Autopsy findings also indicated that, when the man hit his head, some damage to his brain occurred as we Based on what you know about infiammation and the cellular structure of the brain, describe what the pathologist tound in each of the damaged areas of the brain. Nole Be specific. This answer should be at least a paragraph long and contain information pertaining to the infammation and the cellular structure of the brain. A few key words needed microgltia, necrosis, white blood cells Paragraph BIE O Type here to search 5 6 8

Answer 1

Most common cause of stroke is sudden occlusion of blood vessels by thrombus or embolism, which results in loss of oxygen supply to the cerebral tissues. Acute ischemic stroke accounts for about 85% of all case of stroke, the remaining 15% by hemorhagic stroke. Ischemic stroke results from the sudden decrease or loss of blood circulation to an area of brain resulting in loss of neurological function. Brain tissue deprived of oxygen, glucose eventually becomes necrotic, brain inflamation occurs in the necrotic brain tissue, macrophages and neutrophil play a major role in brain inflamation.

Within seconds or minutes after the loss of blood to a region of brain, the ischemic cascade is rapidly initiated, which comprises series of events like oxidative stress, microvascular injury, blood brain barrier dysfunction and post ischemic inflamation, brain cells like astrocytes, oligodendrocytes, endothelium will contribute to triggering post ischemic inflamation by producing inflamatory mediators, inflamatory mediators like cytokines activate infiltrating leukocytes (type of white blood cell) which induces ischemic brain injury in brain cells. all this will ultimately result in cell death of a neuron, microglial cell ( microglial cells account for 10 to 15 % of cells in brain) endothelial cells, the degree and duration of ischemia determines the extent of cerebral damage.