PROVIDE 5 good nucleophile for SN2
Strong Nucleophiles –
· Usually anions with a full negative charge
· Participate in SN2-sort substitutions
EXAMPLES:
:
NaOCH3 (any NaOR),
LiCH3 (any RLi),
NaOH or KOH,
NaCN or KCN,
NaCCR (acetylide anion),
NaNH2,
NaNHR,
NaNR2,
NaI, LiBr, KI, NaN3
===================
PROVIDE 5 good nucleophile for SN1
WeakBases –
· Typically nonpartisan atoms
· Participate in E1-sort substitutions
· Can happen simultaneously with SN1 responses since both happen under comparable conditions (sort of halide, carbocation halfway, impartial nucleophile/base)
EXAMPLES:
H2O, ROH, H2S, RSH
=================================
PROVIDE 3 SOLVENTS for SN2
For a SN2 response, the impact of dissolvable extremity is
typically significantly less, however the capacity (or truly need
there of) of the dissolvable to solvate the nucleophile is the
essential criteria
Solvent |
Dipole moment, m |
CH3OH |
2.87 |
H2O |
1.84 |
DMSO |
3.96 |
DMF |
3.82 |
CH3CN |
3.92 |
PROVIDE 3 SOLVENTS for SN1
SN1 response, the extremity and capacity of the dissolvable to
balance out the transitional carbocation is of fundamental
significance
Solvent |
Dipole moment, m |
CH3CO2H |
1.68 |
CH3OH |
2.87 |
H2O |
1.84 |
Provide 5 good nucleophiles for SN2 ____, ____, ____, ____, ____ Provide 5 nudeophiles for SN1...
2. (1.5 pts) Label the following reagents as Good or Poor Nucleophiles AND as Strong or Weak Bases. OK Na SH 3. (1.5 pt) Predict the productts) of the following reactions, if there are multiple products indicate which, if any, is the major product. Be sure to clearly mark the stereochemistry of chiral carbon atoms and draw multiple products if there is more than one stereoisomer that forms. HCI MeOH H2SO H2 Pd/BaSO4 quinoline 4. (3 pt) For the following...
please help!!! are my answers right??? True Larger atoms are better nucleophiles due to polarizability. False The identity of the nucleophile affects the rate of an SN1 reaction. False SN2 reactions proceed via frontside attack. True Bimolecular reactions tend to be stereoselective. True SN2 reactions invert all stereocenters in a haloalkane. False Cl-, OH-, and H-are good all leaving groups. True Good bases tend to be good nucleophiles arch True Branching adjacent to a reacting carbon slows SN2 reactions due...
Predict the following major products. Provide the name of the mechanism (Sn2, Sn1, E2, or E1). CI ci CH3S 3 N3 1 100 C 100 C CN Br HS N 4 Br 25 C 25 C
Thermodynamics and kinetics of SN1, SN2, E1, and E2 mechanisms. 2. Draw the reaction coordinate diagrams of the following reactions according to the type of mechanisms given and include the following: a) Label the reactant, product, intermediates, and a drawing of the transition state of the rate determining step. If there are multiple E, label the largest E (5 pts) b) State if AG rx is <0 or >0 and make sure your diagram reflects the AGxn. (4 pts) Hint:...
Determine if each of the following statements is true or false 1 Larger atoms are better nucleophiles due to polarizability. 2 The identity of the nucleophile affects the rate of an SN1 reaction. 3 SN2 reactions proceed via frontside attack. 4 Bimolecular reactions tend to be stereoselective. 5 SN2 reactions invert all stereocenters in a haloalkane. 6 Cl-, OH-, and...
(3 pt) For the following reactions: a) Label the substrate (1°, 2°, 3°), reagent (Good/Poor Nu, Strong/Weak Base) and solvent (protic, aprotic). b) Determine what mechanism will predominate (SN1, SN2, E1, or E2). c) Draw the product(s) you would expect to form, paying attention to regioselectivity and stereoselectivity. 4. (3 pt) For the following reactions: a) Label the substrate (1º, 2º, 3º), reagent (Good/Poor Nu, Strong/Weak Base) and solvent (protic, aprotic). b) Determine what mechanism will predominate (SN1, SN2, E1,...
Predict the most likely reaction mechanism (SN1, SN2, E1, E2) and draw all products. Nato=CH₂ E2 ran Br major 2. Draw complete mechanism with arrows for the SN1/E1 mechanism. Check for carbocation rearrangements. CH3 SMI 애 + H₂O7
1. Predict the most likely reaction mechanism (SN1, SN2, E1, E2) and draw all products. CH3 CI + NaOCH2CH3 2. Draw complete mechanism with arrows for the SN1/E1 mechanism. Check for carbocation rearrangements. Hac CH + H2O
30. Late papers not accepted. Work Independently. 1. Predict the most likely reaction mechanism (SN1, SN2, E1, E2) and draw all products. CH₂ Na O=CH₂ Hic Br 2 Draw complete mechanism with arrows for the SNI/E1 mechanism. Check for carbocation rearrangements CH3 + H2O 3. Which is the major product for the following reaction? Y CH + NaOH CH HO HO H₃ CH₂ H₃ HOCH CH₂ H₃ CHE CH₂ CH₂ CH3 CH 4. Name the following including the R/S, E/Z...
4. Predict the products of the following reactions & indicate whether they are most likely to go through an SN2, SN1, E1, or E2 mechanism. NaCN DMSO NaOH CH3OH heat Only one product is formed in the following E2 elimination reaction. Draw an arrow-pushing mechanism for the reaction and provide the correct product structure. Include a 3-D drawing (chair conformation) displaying proper stereochemistry of the transition state to explain formation of only the major product. CH3 •Br NaOCH3 ~"'CHS