Question

2. (1.5 pts) Label the following reagents as Good or Poor Nucleophiles AND as Strong or Weak Bases. OK Na SH 3. (1.5 pt) Predict the productts) of the following reactions, if there are multiple products indicate which, if any, is the major product. Be sure to clearly mark the stereochemistry of chiral carbon atoms and draw multiple products if there is more than one stereoisomer that forms. HCI MeOH H2SO H2 Pd/BaSO4 quinoline 4. (3 pt) For the following reactions: a) Label the substrate (1°, 20, 3°), reagent (Good/Poor Nu, Strong/Weak Base) and solvent (protic, aprotic). b) Determine what mechanism will predominate(SN1, SN2, El, or E2). c) Draw the product(s) you would expect to form, paying attention to regioselectivity and stereoselectivity. Br MeOH SN1 E1 SN2 E2 Heat Br NaOH SN1 E1 SN2 E2 DMF Br NaOtBu SN1 E1 SN2 E2 HOtBu heat Cl DBU THF heat Br NaCN SN1 E1 SN2 E2 DMF H20 SN1 E1 SN2 E2 Br

Answer 1

Answer – We are given reagent and need to determine the given reagent is either good nucleophile or poor nucleophile and also need to determine the strong base or weak base.

We know strong nucleophile is the species which can donate the pair of electron very easily and poor is the one which is donating pair of electron less than comparatively strong nucleophile. Nucleophilicity is inversely proportional to electronegativity and directly proportional to electron density.

We know the base is the species which can abstract the proton from another species. Strong base easily abstracts the proton and weak base is not easily abstract the proton. So the following reagents are classified as follows –

OH Strong Strong Poor Poor Poor OK Na Base Weak Weak Strong Strong