Solution:
[1] (a) The reaction involved in the converion of an amide to its 1o amine with 1 C atom less, is called Hoffmann bromamide reaction. The reaction mechanism is given below.
[1] (b) The synthetic route for compound (i) & (ii) are given below along with reagents.
Note:- TBDMSCl is Tert-Butyldimethylsilylchloride
[1] (a) (6 pts) Propose a reasonable mechanism for the following reaction. D CONHE aq. NOH...
6. Draw the arrow-pushing mechanism for this transformation. 2 NaOH(aq) 7. Propose routes to make the products shown from the reactants. Give all reagents required and draw all stable, neutral intermediate compounds. You will need more than one step in each case
6. Draw the arrow-pushing mechanism for this transformation 2 NaOH(aq) 7. Propose routes to make the products shown from the reactants. Give all reagents required and draw all stable, neutral intermediate compounds. You will need more than one step in each case. OH CH CH3 CH3 HyC H3C н,с Br он Br CH3 Brunker CHEM332
Give a reasonable synthesis for each of the following compounds from the indicated starting materials. You may use any other organic or inorganic reagents you wish unless otherwise indicated. The desired product for each reaction you propose must be the one of the predominant products. Give the reactants, conditions (where appropriate) and products of each synthetic step. If equal mixtures are anticipated (i.e. ortho / para products) then indicate where separations are needed. NO MECHANISMS! [6 points 2. Give a...
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Retrosynthetic Analysis 12. Give a reasonable synthesis for each of the following compounds from the indicated starting materials. You may use any other organic or inorganic reagents you wish unless otherwise indicated. The desired product for each reaction you propose must be the one of the predominant products. Give the reactants, conditions (where appropriate) and products of each synthetic step. NO MECHANISMS! [8 points] NH ONH2 Make starting with
Propose a reasonable mechanism for the following reaction (10 pts) NH OH OH -
5. Propose a reasonable mechanism to account for the following reaction. (5 pts) H2O/H2SO4
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1. Propose synthetic routes to prepare the compounds from the shown starting materials in 2 steps. Use any reagents as necessary: OH U from OH
Propose a reasonable mechanism for the following transformation, starting from aniline, using curved arrow notation. 4. Propose a reasonable mechanism for the following transformation, starting from aniline, using curved arrow notation. (3 pts) ОН NH2 NaNO2, HCI 0 °C