Question

Identify the missing reagents 1 & 2; draw the final organic product(s) C.

Identify the missing reagents 1 & 2; draw the final organic product(s) C.

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Answer #1
Concepts and reason

A reaction sequence and the final product is given. The reagents need to be selected from the given set of reagents. A chemical reaction involves the reaction between two or more substances. The reaction process is helped by the reagents that help in bringing about the transformation of the reactant into product.

Fundamentals

Every reagent has a specific role and help in achieving the final product.

Periodic acid (HIO4)\left( {{\rm{HI}}{{\rm{O}}_4}} \right) is an important reagent that is used in the oxidation of vicinal diols to corresponding carbonyl compounds.

OsO4{\rm{Os}}{{\rm{O}}_4} that is osmium tetroxide is used for cis hydroxylation of alkenes.

Na in liquid NH3{\rm{N}}{{\rm{H}}_3} is used for the conversion of alkynes to trans alkenes.

The reaction is as follows:

Reagent 1
Na or Li
-CEC-
HC=CH
liquid NH3
Trans alkene

The trans alkene is converted to syn diols as follows:

Reagent 2
1) OsO4
HO
HC=CH
2) NaHSO3, H20
Trans alkene
Syn - diol

The syn diol undergoes oxidation as follows:

Но
он
Reagent 3
HIO4
ан
acetaldehyde
propionaldehyde
Syn - diol

Ans:

Hence, the given transformation can be carried out by using following set of reagents:

Reagent 1
НО
Reagent 2
1) Os04
ОН
LEDER
Na or Li
111lll
c=
HC=CH
liquid NH3
2) NaHSO3, H20
Reagent 3
HIO4
which

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