Question

PLEASE SHOW WORK!

10) The following two questions use the pedigree shown below. Calculate the inbreeding coefficient for the child marked with a "" in the pedigree below. Assume FA- A) 1/32 B) 1/256 C) 1/64 D) 1/128 11) Recessive alleles of the Cf gene that cause cystic fibrosis are present at a frequency of 0.03 in the general population. How much is the inbred child's risk for being afflicted by cystic fibrosis increased relative to the general population? The child is the one labeled with a "" in the preceding pedigree. A) 15 B) 1.5 C) 32 D) 3.2 12) Consider the following data obtained by analyzing Neurospora ascospores produced after crossing a wild type strain to a mutant stain. 6 segregation patterns were observed; the number of each are shown.A indicates that a spore is phenotypically wild type and"- that it is mutant for a gene called T. How far is the T gene from the centromere in map units (cM)? 459 451 20 22 25 23 B) 6 C) 9 D) 18 A) 4.5

Answer 1

If the number of individuals along the path is n, and the inbreeding coefficient for the common ancestor is F, the total contribution to the inbreeding coefficient is:

$\fn_cm Inbreeding\,coefficient\,=\, [\frac{1}{2}]^{n}\,x\,(1+F)$

F=0,

$\fn_cm Inbreeding\,coefficient\,=\, [\frac{1}{2}]^{7}\,x\,(1+0)$

$\fn_cm Inbreeding\,coefficient\,=\, \frac{1}{128}$