Question

During development of the neuromuscular junction, several developing nerve cells send out axons to the muscle. The first one to reach the muscle sends an autocrine signal to itself to continue to make neurotrophin and a signal to the other nerve cells in the immediate area that inhibits their ability to receive neurotrophin. The lack of neurotrophin induces apoptosis in these extra neuronal cells. Put the following steps in this apoptotic pathway in the proper order starting with "Binding of Bad to the Bcl-2 mitochondrial membrane protein.

      -       1.       2.       3.       4.       5.      

Binding of Bad to the Bcl-2 mitochondrial membrane protein.

      -       1.       2.       3.       4.       5.      

Cleavage of actin and DNA.

      -       1.       2.       3.       4.       5.      

Cleavage of procaspase-3 converting it to active caspase-3.

      -       1.       2.       3.       4.       5.      

Release of cytochrome c from the outer mitochondrial membrane.

      -       1.       2.       3.       4.       5.      

Cleaving of the procaspase-9 protein converting it to active caspase-9.

Answer 1

Binding of hendaial Photeii membdane membrane ts active vaapare a caopare 3