Question

Question 16 What is the purpose of adding phosphoric acid in aspirin synthesis A) enhance the nucleophilicity of the OH of salicylic acid B) enhance the electrophilicty of acetic anhydride enhance the nucleophilicity of acetic anhydride D) enhance the electrophilicty of the carbonyl of salicylic acid А 8 С

Answer 1

Answer:

16.

In aspirin synthesis, phosphoric acid is added to enhance the electrophilicity of the anhydride molecule.

In acidic environment the oxygen of one carbonyl group of the anhydride takes a proton to form positively charged Oxonium species. This positive charge on the oxygen makes the carbonyl carbon more electrophilic and thus the OH group of salicylic acid can carry out a nucleophilic attack on that easily.

17.

The correct statements about Electrophilic aromatic substitution are-

A) Ferrocene is more reactive than benzene towards Electrophilic aromatic substitution reactions. Because Ferrocenes are more electron rich than benzene.

C) Ferrocenes are more reactive than acetyl ferrocene. Acetyl groups are deactivating substituent because they withdraw electrons from the ring through -M effect making the Ferrocene compound less reactive.

18.

Salicylic acid is converted to aspirin to

A) reduce pH of the pain reliever that prevents stomach irritation.

Aspirin itself is a weak acid and it lowers pH.