Question

Which of the following scenarios will lead to the protein to be secreted out of the cell? Select one: a. A protein, normally localized to the Golgi apparatus, to which the Signaling peptide is deleted b. More than one of the describe scenarios will cause the protein to be secreted outside the cell c. A protein that is normally secreted, to which its Signaling peptide is deleted and replaced with a PLS d. A protein normally localized to the nucleus, to which the NLS is deleted e. A protein that is normally localized to the mitochondria is mutated to add a Signaling peptide at it's N terminus.

Answer 1

The correct answer is option e- A protein that is normally localized to the mitochondria is mutated to add a signalling peptide at its N Terminus.

Explanation: Signal peptide helps in transport of proteins to its proper destination and it also helps in secretion f proteins. So if signal sequence is deleted, it cannot be secreted.so, option a and c is not correct. If NLS is deleted from a protein , a protein after entry into a cell interior by endocytosis cannot move to the nucleus as NLS help the protein to be localized into the nucleus. So option d is also not correct. A mitochondrial protein , if got a signaling peptide at its N terminus, it will be secreted outside. So the correct answer is option e. As only one option is correct, option b is also not correct.