Question

The Maturation promoting factor (MPF) is a complex formed by a cyclin dependent kinase (CDK) and a cyclin. MPF allows for the transition from G2 to M checkpoint. A mutation preventing the binding of cyclin to CDK will... Select one: a result in more cells arrested in the G2 to M checkpoint b. cause uncontrolled cell division and eventually a tumor c. More than one listed option are possible consequences of this event d. increase in the phosphorylation of the CDK targets e. increase in the phosphorylation of the cyclin targets

Answer 1

Answer:

(a) result in more cells arrested in the G2 to M checkpoint.

As it is given that the progression of cell cycle is dependent on MPF and MPF production is dependent on association of cyclin and CDK complex, without their association, the progression of cell cycle would stop. The association of cyclin-CDK complex activates the CDK as a phosphorylation agent and cyclin directs it to act upon next target molecules for progression of cell cycle. So without association, there will be no phosphorylation (never increase). There will be no tumour as the progression of the cell cycle would be stopped.

Give a thumbs up if you like the answer. Thank you:)